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Division of Natural Sciences & MathematicsDepartment of Chemistry & Biochemistry

Faculty & Staff

Chemistry & Biochemistry

Faculty & Staff

Lawrence Berliner

Berliner, Lawrence J.

Professor
Phone: 303-871-7476
Email: berliner@du.edu
http://portfolio.du.edu/lberlin1

More about Lawrence Berliner

The Berliner group uses unpaired electrons to probe dynamics and distances between selected sites on a protein that are sensitive to it's unique structure and function. This may be substituting a paramagnetic lanthanide for a calcium ion or by covalently adding novel aminoxyl radical probes called spin labels. The spectral analyses, including distance measurements between probes, provides insight on how a protein folds and important conformational changes associated with function. Additionally we use molecules called spin traps to characterize free radicals in-vivo. Some studies are important to health problems ranging from ischemia/heart disease to infection shock. We pioneered development of techniques and instrumentation for live animal applications which are now routine in unique laboratories around the world. We also utilize MRI in these in vivo applications. Current research involves a homologous family of calcium binding proteins that have tumor killing properties in molten globule form. These also form amyloid aggregates and fibrils, which may be excellent models for neurodegenerative disease proteins. The free radical project involves intermediates of a common blood pressure lowering drug that may lead to heart disease. The work includes protein expression and labeling, spectroscopic measurements by magnetic resonance, fluorescence, CD and subsequent data analysis.

Emily Barter

Barter, Emily

Teaching Assistant Professor
Phone: 303-871-2746
Location: Boettcher West 222
Email: emily.barter@du.edu

More about Emily Barter

I teach the Science of Contemporary Issues courses. Science of Contemporary Issues is a three-quarter sequence focused on real-world applications of chemistry. The sequence includes both lecture and laboratory components.

Chapman, Erich

Assistant Professor
Phone: 303-871-3681
Location: Seeley G. Mudd 123
Email: erich.chapman@du.edu

More about Erich Chapman

Research in the Chapman lab explores connections between RNA structure and function in contexts related to human disease. To do so our team draws upon a variety of biochemical, biophysical and structure-based approaches in order to interrogate important questions regarding mRNA turnover and stability. The long term goals of our studies are to advance understanding of underlying mechanisms of eukaryotic gene expression and unlock the potential for new types of RNA-based medicines. The Chapman lab is supported in part by funding from the National Institutes of General Medical Science.

Bryan Cowen

Cowen, Bryan

Assistant Professor
Phone: 303-871-2981
Location: Seeley G. Mudd 132
Email: bryan.cowen@du.edu
http://portfolio.du.edu/bcowen

More about Bryan Cowen

The Cowen group’s research program focuses on the development of new synthetic methods for the preparation of small, functional organic compounds. Special emphasis centers on the discovery of unique asymmetric reactions to enable the selective construction of complex chiral molecular architectures. The design of small-molecule catalysts and ligands for both non-metal and metal-mediated transformations are key research activities ongoing in the laboratory. Additionally, the investigation of detailed mechanistic reaction pathways is of paramount importance to the maturation of any new synthetic method. A particular goal of our efforts in chemical synthesis is to produce valuable end products for potential pharmaceutical or material-based applications.

Gareth Eaton

Eaton, Gareth

Professor
Phone: 303-871-2980
Location: Seeley G. Mudd 153
Email: gareth.eaton@du.edu
http://portfolio.du.edu/geaton

More about Gareth Eaton

The Eaton group develops new electron paramagnetic resonance (EPR) methods and instrumentation to address significant biochemical and chemical problems.  A major current emphasis is on EPR methods to improve sensitivity and solve biomedical problems.  In collaboration with research groups at the University of Chicago and University of Maryland we are developing methods for imaging local oxygen in vivo and methods for in vivo study of the physiology of tumors.  Our team includes chemists, biochemists, physicists, and engineers.   Our instrumentation includes state of the art Bruker BioSpin and locally-constructed spectrometers.   Dissemination to the research community, in addition to over 300 research papers and reviews, includes a book on EPR imaging, a book on quantitative EPR, and major book chapters about electron spin relaxation and rapid scan EPR.

Sandy Eaton

Eaton, Sandra

Professor
Phone: 303-871-3100
Location: Seeley G. Mudd 178 and Olin 202
Email: sandra.eaton@du.edu
http:/portfolio.du.edu/seaton

More about Sandra Eaton

The Eaton group develops new electron paramagnetic resonance (EPR) methods and instrumentation to address significant biochemical and chemical problems.  A major current emphasis is on EPR methods to improve sensitivity and solve biomedical problems.  In collaboration with research groups at the University of Chicago and University of Maryland we are developing methods for imaging local oxygen in vivo and methods for in vivo study of the physiology of tumors.  Our team includes chemists, biochemists, physicists, and engineers.   Our instrumentation includes state of the art Bruker BioSpin and locally-constructed spectrometers.   Dissemination to the research community, in addition to over 300 research papers and reviews, includes a book on EPR imaging, a book on quantitative EPR, and major book chapters about electron spin relaxation and rapid scan EPR.

Alex Huffman

Huffman, Alex

Assistant Professor
Phone: 303-871-4404
Location: Seeley G. Mudd 180
Email: alex.huffman@du.edu
http://tinyurl.com/HuffmanLabDU

More about Alex Huffman

My research focuses on atmospheric aerosols (small particles suspended in air), including their roles in various environmental processes and human health concerns. We deploy instrumentation to field sites for in-situ ambient monitoring and also work to develop and characterize new analytical techniques. Several of my current projects revolve around the detection of biological aerosols (e.g. fungal spores, bacteria, pollen) with the goal of understanding how these particles may contribute to cloud formation and climate cycles.

Ichire, Ogar (Leo)

Teaching Assistant Professor
Phone: 303-871-2985
Location: Olin 203
Email: ogar.ichire@du.edu

More about Ogar Ichire

I teach the organic chemistry sequence of courses.

John Latham

Latham, John

Assistant Professor
Phone: 303-871-2533
Location: Seeley G. Mudd 251
Email: john.latham@du.edu
http:/portfolio.du.edu/lathamlab

More about John Latham

Our group is interested in understanding the structure-function relationship of radical-S-adenosylmethionine proteins that are used to modify small peptides. We use traditional enzymology techniques (e.g. kinetic analysis and site directed mutagenesis) paired with biophysical techniques (e.g. isothermal calorimetry, electrochemistry, and surface plasmon resonance spectroscopy) to understand the structural attributes that lead to chemical function.

Michelle Knowles

Knowles, Michelle

Assistant Professor
Phone: 303-871-6698
Location: Seeley G. Mudd 101
Email: michelle.knowles@du.edu
http://michelleknowles.wix.com/knowleslab

More about Michelle Knowles

The goal of our research is to understand the molecular mechanism of membrane proteins. We use biophysical techniques, such as imaging and spectroscopy, to temporally map proteins on the plasma membrane of living cells and model membrane systems. We are particularly interested in proteins that facilitate the fusion of intracellular vesicles with the plasma membrane and proteins that regulate the flow of chemicals across the plasma membrane.

Andrei Kutateladze

Kutateladze, Andrei

Professor
Phone: 303-871-2995
Email: a.kutateladze@du.edu
http://kgroup.du.edu

More about Andrei Kutateladze

The K-group's interests are in applied and theoretical organic photochemistry. We discover and study new photochemical reactions, pursuing a better understanding of the nature and reactivity of excited states. This knowledge is employed to develop practical applications ranging from expeditious synthesis of complex molecular scaffolds to designing new assays for high throughput bioanalytical applications and combinatorial screening, useful for the thriving field of chemical biology. We continue to develop innovative methodologies for detection and photochemical pre-amplification of molecular recognition events, both in solution and on a chip. These techniques are being applied to medicinal chemistry, helping identification of novel drug candidates and lead compounds. Organic photochemistry is an exciting and growing area, offering opportunities in many fields, including chemistry, biochemistry, and chemical biology!

Brian Majestic

Majestic, Brian

Assistant Professor
Phone: 303-871-4135
Location: Seeley G. Mudd 151
Email: brian.majestic@du.edu

More about Brian Majestic

The research interests in the Majestic lab focus around atmospheric particulate matter (PM). We are presently interested in understanding transformations of transition metals in atmospheric systems. Currently, we are studying oxidation state and speciation changes of iron as it is processed in cloud water and upon interaction with “urban” gases, such as sulfur dioxide. In addition, we are interested in better quantifying human exposure of atmospheric metals. Therefore, we are involved in field studies in and around the Denver area, the American Southwest, and China. The work done in our lab has implications near and far: on how we understand the human health effects of atmospheric metals to providing insights into the global iron cycle. Our primary tools of measurement include inductively coupled plasma mass spectrometry (ICP-MS) and long pathlength UV-vis spectrophotometry.

Martin Margittai

Margittai, Martin

Associate Professor
Phone: 303-871-4135
Location: Seeley G. Mudd 253
Email: martin.margittai@du.edu

More about Martin Margittai

The folding of proteins into correct three-dimensional structures and the control over their intermolecular interactions is of central importance to the proper functioning of cells. A complex machinery has evolved that assists in folding and ensures proper protein contacts. Malfunctioning of this machinery can lead to protein misfolding and result in fatal human diseases including Parkinson's disease and Type II diabetes. A characteristic feature of most misfolding diseases is the deposition of proteins into fibrillar inclusions and plaques. Research in our lab focuses on the misfolding of the microtubule associated protein tau. Tau fibrils are found in numerous neurodegenerative diseases including Alzheimer?s disease and progressive supranuclear palsy. The formation of fibrils is a multistep process starting from monomeric disordered tau. The conformational changes leading to oligomers and the progression into mature fibrils are only poorly understood. Our lab uses a broad range of biophysical approaches to obtain structural insights into the misfolding of tau. We are furthermore interested in elucidating the cellular mechanisms that control tau function and prevent fibril formation. A detailed molecular understanding of the tau structures involved, their conformational transitions, and cellular control appears to be an important prerequisite towards developing new drugs that intervenein the aggregation process.

Brian Michel

Michel, Brian

Assistant Professor
Phone: 303-871-2595
Location: Seeley G. Mudd 232
Email: brian.michel@du.edu
https://portfolio.du.edu/Brian.Michel/page/51802

More about Brian Michel

We are an organic synthesis group that utilizes mechanistic insight to solve problems in catalysis and small molecule probe design. We are currently  focused on developing new catalytic reactions involving transition metals. Additionally, we are interested in developing probes for the detection of biologically relevant small molecule analytes.

Keith Miller

Miller, Keith

Associate Professor
Phone: 303-871-7510
Location: Seeley G. Mudd 105
Email: kmiller3@du.edu
http:/portfolio.du.edu/kmiller3

More about Keith Miller

The research interests of the Miller group are very interdisciplinary in nature. They can be broadly defined in three major areas: 1) fundamental and applied research in separation sciences with applications focused in environmental contaminants, 2) research in water treatment technology focused in novel sorbent preparation and wet-oxidation for the removal of chemicals of concern from wastewaters (agricultural, industrial and municipal), and 3) development of analytical techniques for the analysis of food contaminants.

Debbie Mitchell

Mitchell, Debbie

Teaching Assistant Professor
Phone: 303-871-4182
Location: Boettcher West 213
Email: debbie.mitchell@du.edu
http://portfolio.du.edu/sec

More about Debbie Mitchell

I teach a variety of first and second-year chemistry courses. I am also the director of the Science and Engineering center in the library.

Balasingam Murugaverl

Murugaverl, Balasingam

Teaching Associate Professor
Phone: 303-871-2947
Location: Olin 209
Email: bmurugav@du.edu
http://portfolio.du.edu/bmurugav

More about Balasingam Murugaverl

I teach a variety of courses from freshman to graduate level while being the director of undergraduate laboratories. I also volunteer as the manager of the mass spectrometry facilities. My research interests are applied in nature, like to find solutions to immediate real life scientific problems. One of my current researches involves the development of superior chlorine resistant reverse osmosis membrane for water purification. "Water, water, everywhere, nor any drop to drink", can apply as much to countries and societies without fresh water supply to military operations. Development of advanced membranes with chlorine resistance along with enhanced water flux and salt rejection requires more comprehensive understanding of the molecular level mechanisms of structure property relationships. This involves; synthesis of novel monomers and polymers, use of state-of the- art characterization techniques and field testing. Our systematic approach for this problem has guided us to the creation of a newer polyamide RO membrane with superior chlorine resistance and RO properties. A patent has been granted for this invention.

Todd Wells

Wells, Todd

Teaching Assistant Professor
Phone: 303-871-2439
Location: Seeley G. Mudd 130
Email: todd.wells@du.edu

More about Todd Wells

I teach the General Chemistry sequence of courses.

Staff

Gary Bishop

Bishop, Gary

Senior Research Engineer
Phone: 303-871-2584
Location: Seeley G. Mudd 115
Email: gbishop@du.edu

More about Gary Bishop

Donald Stedman and Gary Bishop worked together at the leading edge of technology which they invented, and patented, to measure the emissions of motor vehicles as they drive by. The remote sensing system monitors various vehicle emissions in a realistic on-road situation, at a rate of 5,000 readings per day. On-road remote sensing generates large data bases of emissions measurements which we use toinvestigate the effectiveness of the various government programs that attempt to reduce motor vehicle emissions. We have monitored over three million motor vehicles in twenty countries, and the list continues to expand.

Mary Shonk

Shonk, Mary

Assistant to the Chair
Phone: 303-871-2436
Location: Olin 202
Email: mshonk@du.edu

Chris Stutzman

Stutzman, Christine

Office Assistant
Phone: 303-871-2435
Location: Olin 202
Email: cstutzma@du.edu