The Gareth and Sandra Eaton research group is developing electron paramagnetic resonance (EPR) instrumentation and methodology to monitor local oxygen concentration in living systems. This project brings together engineers, chemists, computer scientists, and biologists. The goal is to use knowledge of oxygen concentrations to improve radiation therapy for tumors and treatment of circulation problems in diabetics. This work is done in collaboration with Professor Howard Halpern at the University of Chicago and Professor Gerald Rosen at the University of Maryland. Further information about this project can be found on its website.
To improve sensitivity of the measurements we are developing a new detection technique for EPR signals and better ways to reconstruct information into images.
A second interest of our group is measurement of distances between unpaired electrons in biomolecules that are present as native centers or added as probes. These measurements help us to understand assembly of subunits or conformational changes.