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Natural Sciences & Mathematics


Molecular and Cellular Biophysics


Selected publications in the last five years

Joseph Angleson

Reinick CL, Liang L, Angleson JK, Dores RM. Functional expression of Squalus acanthias melanocortin-5 receptor in CHO cells: Ligand selectivity and internaction with MRAP Eur J Pharmacol. 2012 Apr 5;680(1-3):1-7. Epub 2012 Jan 31.

Veo K, Reinick C, Liang L, Moser E,Angelson JK, Dores RM. Observations on the ligand selectivity of the melanocortin 2 receptor. Gen Comp Endocrinol. 2011 May 15;172(1):3-9. Epub 2011 Apr 8. Review. PubMed PMID: 21501611.

Chen Q, Layton K, Veo K,Angelson JK, Dores RM. α-TC1.9 cells--a model system for analyzing the endoproteolytic processing of POMC. Gen Comp Endocrinol. 2011 May 15;172(1):96-106. Epub 2011 Jan 4. PubMed PMID: 21211538.

Sadler SE,Angelson JK, Dsouza M. IGF-1 receptors in Xenopus laevis ovarian follicle cells support the oocyte maturation response. Biol Reprod. 2010 Mar;82(3):591-8. Epub 2009 Nov 18. PubMed PMID: 19923252.

Scott Barbee

Hillebrand J, Pan K, Kokaram A, Barbee S, Parker R and Ramaswami M (2010). The Me31B DEAD-box helicase localizes to postsynaptic foci and regulates expression of a CaMKII reporter mRNA in dendrites of Drosophila olfactory projection neurons. Front. Neural Circuits 4:121.

Cziko A-M, McCann CT, Howlett IC, Barbee SA, Duncan R, Luedemann R, Zarnescu D, Zinsmaier KE, Parker RR, Ramaswami M (2009). Genetic modifiers of dFMR1 encode RNA granule components in Drosophila. Genetics 182(4):1051-1060.

Kwak JE, Drier E, Barbee SA, Ramaswami M, Yin JCP, Wickens M (2008). GLD2 poly(A) polymerase is specifically required for long-term memory. PNAS. 105(38):14644-14649.

Satterlee J, Barbee S, Jin P, Krichevsky A, Salama S, Schratt G, Wu D-Y (2007). Non-coding RNAs in the brain. J Neurosci. 27(44)11856-9.

Hillebrand J*, Barbee SA*, Ramaswami M (2007). P-body components, microRNA regulation, and synaptic plasticity. ScientificWorldJournal. 7:178-90. * Co-first authors.

Todd Blankenship

Simões Sde M, Blankenship JT, Weitz O, Farrell DL, Tamada M, Fernandez-Gonzalez R, Zallen JA. Rho-kinase directs Bazooka/Par-3 planar polarity during Drosophila axis elongation Dev Cell. 2010 Sep 14;19(3):377-88.

Fabian L, Wei HC, Rollins J, Noguchi T, Blankenship JT, Bellamkonda K, Polevoy G, Gervais L, Guichet A, Fuller MT, Brill JA.  Phosphatidylinositol 4,5-bisphosphate directs spermatid cell polarity and exocyst localization in Drosophila Mol Biol Cell. 2010 May 1;21(9):1546-55. Epub 2010 Mar 17.

Zallen JA, Blankenship JT. Semin Cell Dev Biol. Multicellular dynamics during epithelial elongation 2008 Jun;19(3):263-70. Epub 2008 Feb 2. Review.

Blankenship JT, Fuller MT, Zallen JA. The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity J Cell Sci. 2007 Sep 1;120(Pt 17):3099-110. Epub 2007 Aug 14.

Gareth Eaton and Sandra S. Eaton

Deconvolution of Sinusoidal Rapid EPR Scans, M. Tseitlin, G. A. Rinard, R. W. Quine, S. S. Eaton, and G. R. Eaton, J. Magn. Reson. 208, 279-283 (2011).

Use of the Frank Sequence in EPR, M. Tseitlin, R. W. Quine, S. S. Eaton,G. R. Eaton, H. J. Halpern, and J. H. Ardenkjaer-Larsen, J. Magn. Reson. 209, 306-309 (2011).

A General Purpose Q-Measuring Circuit using Pulse Ring-Down, R. W. Quine, D. G. Mitchell, and G. R. Eaton, Magn. Reson. Engineering, 39B, 43-46 (2011).

Electron Transfer Flavoprotein Domain II Orientation Monitored using Double Electron-Electron Resonance Between an Enzymatically Reduced, Native FAD Cofactor and Spin Labels, M. A. Swanson, V. Kathirvelu, T. Majtan, F. E. Frerman, G. R. Eaton, and S. S. Eaton, Protein Science 20, 610-620 (2011).

Reconstruction of the first derivative EPR spectrum from multiple harmonics of the field-modulated CW signal, M. Tseitlin, S. S. Eaton, and G. R. Eaton, J. Magn. Reson. 209, 277-281 (2011).

Comparison of Continuous Wave, Spin Echo, and Rapid Scan EPR of Irradiated Fused Quartz, D. G. Mitchell, R. W. Quine, M. Tseitlin, V. Meyer, S. S. Eaton, and G. R. Eaton, Radiation Measurements 46, 993-996 (2011).

Calix[4]arene nitroxide tetraradical and octaradical, A. Olankitwanit, V. Kathirvelu, S. Rajca, G. R. Eaton, S. S. Eaton, and A. Rajca, Chem. Commun. 47, 6443-6445 (2011).

Electron Spin Relaxation and Heterogeneity of the 1:1 α,γ-Bisdiphenylene-β-phenylallyl (BDPA) : Benzene Complex, D. G. Mitchell, R. W. Quine, M. Tseitlin, R. T. Weber, V. Meyer, A. Avery, S. S. Eaton, and G. R. Eaton, J. Phys. Chem. B 115, 7986-7990 (2011).

Rapid Frequency Scan EPR, M. Tseitlin, G. A. Rinard, R. W. Quine, S. S. Eaton, and G. R. Eaton, J. Magn. Reson. 211, 156-161 (2011).

Use of polyphase continuous excitation based on the Frank sequence for EPR and EPR Imaging, M. Tseitlin, R. W. Quine, S. S. Eaton, G. R. Eaton, J. Magn. Reson. 211, 221-227 (2011).

Relaxation Times and Line Widths of Isotopically-Substituted Nitroxides in Aqueous Solution at X-band, J. R. Biller, V. Meyer, H. Elajaili, G. M. Rosen, J. P.Y. Kao, S. S. Eaton, and G. R. Eaton, J. Magn. Reson. 212, 370-377 (2011).

Digital EPR with an arbitrary waveform generator and direct detection at the carrier frequency, M. Tseitlin, R. W. Quine, G. A. Rinard, S. S. Eaton, and G. R. Eaton, J. Magn. Reson. 213, 119-125 (2011).

Impact of Chlorine Substitution on Spin Lattice Relaxation of Triarylmethyl and 1,4-Benzosemiquinone Radicals in Glass-forming Solvents between 25 and 295 K, V. Kathirvelu, G. R. Eaton, and S. S. Eaton, Appl. Magn. Reson. 37, 649-656 (2010). PMC2818603

A Spirocyclohexyl Nitroxide Amino Acid Spin Label for Pulsed EPR Distance Measurements, A. Rajca, V. Kathirvelu, S. K Roy, M. Pink, S. Rajca, S. Sarkar, S. S. Eaton, and G. R. Eaton, Chem. Eur. J. 16, 5778-5782 (2010).

A Wire Crossed-Loop-Resonator for Rapid Scan EPR, G. A. Rinard, R. W. Quine, J. R. Biller, and G. R. Eaton, Concepts Magn. Reson. B, Magn. Reson. Engineer. 37B , 86-91 (2010).

Combining Absorption and Dispersion Signals to Improve Signal-to-noise for Rapid Scan EPR Imaging, M. Tseitlin, R. W. Quine, G. A. Rinard, S. S. Eaton, and G. R. Eaton. J. Magn. Reson. 203, 305-310 (2010).

A Very Fast Switched Attenuator Circuit for Microwave and R.F. Applications, R. W. Quine, M. Tseytlin, S. S. Eaton, and G. R. Eaton, Conc. Magn. Reson. B, Magn. Reson. Engineer, 37B, 39-44 (2010).

Quantitative Rapid Scan EPR Spectroscopy at 258 MHz, R. W. Quine, G. A. Rinard, S. S. Eaton, and G. R. Eaton, J. Magn. Reson. 205, 23-27 (2010).

A Signal-to-Noise Standard for Pulsed EPR, G. R. Eaton, S. S. Eaton, R. W. Quine, D. Mitchell, V. Kathirvelu, and R. T. Weber, J. Magn. Reson. 205, 109-113 (2010).

Background Removal Procedure for Rapid Scan EPR, M. Tseitlin, T. Czechowski, R. W. Quine, S. S. Eaton, and G. R. Eaton, J. Magn. Reson. 196, 48-53 (2009).

A Linear Magnetic Field Scan Driver, R. W. Quine, T. Czechowski, and G. R. Eaton, Conc. Magn. Reson. B (Magn. Reson. Engin.) 35B, 44-58 (2009).

Electron Spin Relaxation Rates for Semiquinones between 25 and 295 K in Glass-Forming Solvents, V. Kathirvelu, H. Sato, S. S. Eaton and G. R. Eaton, J. Magn. Reson. 198, 111-120 (2009).

Relaxation Rates for Spirocyclohexyl Nitroxyl Radicals are Suitable for Interspin Distance Measurements at Temperatures up to about 125 K, V. Kathirvelu, C. Smith, C. Parks, Md. A. Mannan, Y. Miura, K. Takeshita, S. S. Eaton, and G. R. Eaton, Chem. Commun., 454-456 (2009).

Interaction of Radical Pairs Through-Bond and Through-Space: Scope and Limitations of the Point-Dipole Approximation in Electron Paramagnetic Resonance Spectroscopy, C. Riplinger, J. P. Y. Kao, G. M. Rosen, V. Kathirvelu, G. R. Eaton, S. S. Eaton, A. Kutateladze, F. Neese, J. Amer. Chem. Soc. 131, 10092-10106 (2009).

DEER Distance Measurement Between a Spin Label and a Native FAD Semiquinone in Electron Transfer Flavoprotein, M. A. Swanson, V. Kathirvelu, T. Majtan, F. E. Frerman, G. R. Eaton, and S. S. Eaton, J. Amer. Chem. Soc. 131, 15978-15979 (2009).

Electron Paramagnetic Resonance Characterization and Interspin Distance Measurement of Electron Transfer Flavoprotein‑ubiquinone Oxidoreductase (ETF-QO), A. J. Fielding, R. J. Usselman, N. Watmough, M. Simkovic, F. E. Frerman, G. R. Eaton and S. S. Eaton, J. Magn. Reson. 190, 222-232 (2008).

Impact of Mutations on the Midpoint Potential of the [4Fe-4S]+ Cluster and on the Catalytic Activity in Electron Transfer Flavoprotein-ubiquinone Oxidoreductase (ETF-QO), R. J. Usselman, A. J. Fielding, F. E. Frerman, G. R. Eaton, and S. S. Eaton, Biochemistry 47, 92-100 (2008).

Electron spin-lattice relaxation of nitroxyl radicals in temperature ranges that span glassy solutions to low-viscosity liquids, H. Sato, S. E. Bottle, J. P. Blinco, A. S. Micallef, G. R. Eaton, and S. S. Eaton, J. Magn. Reson. 191, 66-77 (2008).

Impact of electron-electron spin interaction on electron spin relaxation of nitroxide diradicals and tetraradical in glassy solvents between 10 and 300 K, H. Sato, V. Kathirvelu, G. Spagnol, S. Rajca, S. S. Eaton, and G. R. Eaton, J. Phys. Chem. B 112, 2818-2828 (2008).

The Iron-Sulfur Cluster of Electron Transfer Flavoprotein-ubiquinone Oxidoreductase (ETF-QO) is the Electron Acceptor for Electron Transfer Flavoprotein, M. A. Swanson, R. J. Usselman, F. E. Frerman, G. R. Eaton, and S. S. Eaton, Biochemistry 47, 8894-8901 (2008).

Regularized Optimization (RO) Reconstruction for Oximetric EPR Imaging, M. Tseitlin, T. Czechowski, S. S. Eaton and G. R. Eaton, J. Magn. Reson. 194, 212-221 (2008).

Electron-Electron Distances in Spin-Labeled Low-Spin Metmyoglobin Variants by Relaxation Enhancement, D. Ulyanov, B. E. Bowler, G. R. Eaton, and S. S. Eaton, Biophysical Journal 95, 5306-5316 (2008).

Comparison of Maximum Entropy and Filtered Back-Projection Methods to Reconstruct Rapid-Scan EPR Images, M. Tseitlin, A. Dhami, S. S. Eaton, and G. R. Eaton, J. Magn. Reson. 184, 157-168 (2007).

Electron Spin Lattice Relaxation of V(IV) Complexes in Glassy Solutions between 15 and 70 K, A. J. Fielding, D. B. Back, M. Engler, B. Baruah, D. C. Crans, G. R. Eaton, and S. S. Eaton, ACS Symposium Series 974, 364-375 (2007).

Electron Spin Relaxation in x-Lithium Phthalocyanine, H. Sato, L. A. Dalton, D. Ha, R. W. Quine, S. S. Eaton, and G. R. Eaton, J. Phys. Chem. B 111, 7972-7977 (2007).

Electron Spin Relaxation of Radicals in Irradiated Tooth Enamel and Synthetic Hydroxyapatite, H. Sato, B. A. Filas, S. S. Eaton, and G. R. Eaton, Radiation Measurements, 42, 997-1004 (2007).

EPR Free Induction Decay Coherence Observed after a Single-Pulse for Samples with Resolved Multi-line CW Spectra, V. Kathirvelu, H. Sato, R. W. Quine, G. A. Rinard, S. S. Eaton, and G. R. Eaton, Appl. Magn. Reson. 32, 269-281 (2007).

Impact of molecular size on electron spin relaxation rates of nitroxyl radicals in glassy solvents between 100 and 300 K, H. Sato, V. Kathirvelu, A. Fielding, J. P. Blinco, A. S. Micallef, S. E. Bottle, S. S. Eaton, and G. R. Eaton, Mol. Phys 105, 2137-2151 (2007).

Kingshuk Ghosh

Evidence of Multiple Folding Pathways for the Villin Headpiece Subdomain. L. Zhu, K. Ghosh, M. King, T. Cellmer, O. Bakajin and L.J. Lapidus J. Phys. Chem B. 115 12632-12637 (2011)

Physical limits of cells and proteomes. K.A. Dill, K. Ghosh and J.D. Schmit Proc. Natl. Acad. Sci. 108, 17876-17882 (2011).

How do thermophilic proteins and proteomes withstand high temperature? L. Sawle, K. Ghosh Biophysical Journal 101 (2011).

Stochastic dynamics of complexation reaction in the limit of small numbers. K. Ghosh J. Chem. Phys. 134, 195101 (2011) (selected in the June 1, 2011 issue of Virtual Journal of Biological Physics Research from AIP and APS)

Modeling stochastic dynamics in biochemical systems with feedback using Maximum Caliber. S. Presse, K. Ghosh and K.A. Dill J Phys. Chem. B 115 6202 (2011).

What Drives Amyloid Molecules To Assemble into Oligomers and Fibrils? J. D. Schmit, K. Ghosh and K. A. Dill Biophysical Journal 100, 450 (2011).

Cellular proteomes have broad distributions of protein stability. K. Ghosh and K.A. Dill Biophysical Journal 99, 3996-4002 (2010).

Dynamical fluctuations in biochemical reactions and cycles. S. Presse, K. Ghosh, R. Phillips and K. A. Dill. Phys Rev E 82, 031905 (2010).

Trajectory approach to two-state kinetics of single particles on sculpted energy landscapes. D. Wu, K. Ghosh, M. Inamdar, H. J. Lee, S. Fraser, K. A. Dill and R. Phillips. Phys. Rev. Lett. 103, 050603 (2009).

Computing protein stabilities from their chain lengths K. Ghosh and K. A. Dill. Proc. Natl. Acad. Sci. 106(26), 10649-10654 (2009).

Theory for protein folding cooperativity: helix-bundles. K. Ghosh and K. A. Dill, J. Am. Chem. Soc., 131(6), 2306 (2009).

Maximum caliber: A variational approach applied to two-state dynamics. G. Stock, K. Ghosh and Ken. A. Dill, to appear in J. Chem Phys., 128, 194102 (2008).

The ultimate speed limit to protein folding is conformational searching. K. Ghosh, S. B. Ozkan and K. A. Dill, J. Am. Chem. Soc., 129, 11920 (2007)

Measuring Flux Distribution in the Small-Numbers Limit. E. Seitaridou, M. M. Inamdar, R. Phillips, K. Ghosh, K. A. Dill, J. Phys. Chem B, 111, 2288 (2007).

Michelle Knowles

William Birdsong, Leonardo Fierro, Frank G Williams, Valeria Spelta, Ligia A Naves, Michelle K Knowles, Josephine Marsh-Haffner, John P Adelman, Wolfhard Almers, Robert P Elde, Edwin W McCleskey, “Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels.” Neuron, 2010, 68, 739–749.   

Michelle K. Knowles, Sebastian Barg, L. Wan, M. Midorikawa, X. Chen, and Wolfhard Almers, “Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers.”  Proceedings of the National Academy of Sciences (PNAS), 2010, 107 (48), 20810-20815.

Sebastian Barg, Michelle K. Knowles, Lei Wan, Xi Chen, and Wolfhard Almers, “Syntaxin clusters assemble reversibly at sites of secretory granules in live cells.” Proceedings of the National Academy of Sciences (PNAS), 2010, 107 (48), 20804-20809.

Min Wang, Joshua Black, Michelle K. Knowles, Scott M. Reed, “C-Reactive Protein (CRP) Aptamer Binds to Monomeric but not Pentameric form of CRP” Analytical and Bioanalytical Chemistry,  2011, 401(4), 1309-1318.

Dinah Loerke

V. Hyenne, T. Tremblay-Boudreault, R. Velmurugan, B. D. Grant, D. Loerke, J.C. Labbé (2012) "RAB-5 controls the cortical organization and dynamics of PAR proteins to maintain C. elegans early embryonic polarity" PLoS One (in press)

D. Nunez, C. Antonescu, M. Mettlen, A. Liu, S.L. Schmid, D. Loerke, G. Danuser (2011) "Hotspots organize clathrin-mediated endocytosis by efficient recruitment and retention of nucleating resources" Traffic 12(12):1868-1878

D. Loerke, M. Mettlen, S. Schmid, G. Danuser (2011) "Measuring the hierarchy of molecular events during clathrin-mediated endocytosis" Traffic 12 (7): 815-825

M. Mettlen, D. Loerke, D. Yarar, S. Schmid, G. Danuser (2010) "Cargo- and adaptor-specific mechanisms regulate clathrin-mediated endocytosis" Journal of Cell Biology 188 (6): 919-933

A. Liu, D. Loerke, S. Schmid, G. Danuser (2009) "Global and Local Regulation of Clathrin- Coated Pit Dynamics Detected on Patterned Substrates" Biophysical Journal 97 (4): 1038-1047   

M. Mettlen, M. Stoeber, D. Loerke, C. Antonescu, G. Danuser, and S.L. Schmid (2009) "Endocytic Accessory Proteins Are Functionally Distinguished by Their Differential Effects on the Maturation of Clathrin-coated Pits" Molecular Biology of the Cell 20 (14): 3251-3260   

D. Loerke*, M. Mettlen*, D. Yarar, K. Jaqaman, H. Jaqaman, G. Danuser, S. Schmid (2009). "Cargo and dynamin regulate clathrin-coated pit maturation" PLoS Biology 7 (3):e57 (*authors contributed equally)

K. Jaqaman, D. Loerke, M. Mettlen, H. Kuwata, S. Grinstein, S. Schmid, G. Danuser (2008). "Robust single-particle tracking in live-cell time-lapse sequences." Nature Methods 5 (8): 695- 702.

Ji, L., D. Loerke, M. Gardel, G. Danuser (2007). "Probing Intracellular Force Distributions by High-Resolution Live Cell Imaging and Inverse Dynamics." Methods in Cell Biology 83

Nancy Lorenzon

Lorenzon NM, Beam KG (2008). Disease causing mutations of calcium channels. Channels 2:3, 1-17, in press, May/June

Lorenzon NM, Beam KG (2007). Accessibility of targeted DHPR sites to streptavidin and functional effects of binding on EC coupling. J Gen Physiol 130, 379-388

Martin Margittai

Yu X, Luo Y, Dinkel P, Zheng J, Wei G, Margittai M, Nussinov R, Ma B. Cross-seeding and conformational selection between three- and four-repeat human Tau proteins.
J Biol Chem. 2012 Mar 5. [Epub ahead of print]

Dinkel PD, Siddiqua A, Huynh H, Shah M, Margittai M. Variations in filament conformation dictate seeding barrier between three- and four-repeat tau. Biochemistry. 2011 May 24;50(20):4330-6. Epub 2011 May 2. PubMed PMID: 21510682.

Siddiqua A, Margittai M. Three- and four-repeat Tau coassemble into heterogeneous filaments: an implication for Alzheimer disease. J Biol Chem. 2010 Nov 26;285(48):37920-6. Epub 2010 Oct 4. PubMed PMID: 20921227; PubMed Central PMCID: PMC2988394.

Margittai M, Langen R. Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy. Q Rev Biophys. 2008 Aug-Nov;41(3-4):265-97. Review. PubMed PMID: 19079806.

Chen M, Margittai M, Chen J, Langen R (2007). Investigation of alpha-synuclein fibril structure by site-directed spin labeling. J Biol Chem 282, 24970-24979.

David Patterson

Baresova V, Skopova V, Sikora J, Patterson D, Sovova J, Zikanova M, Kmoch S. Mutations of ATIC and ADSL affect purinosome assembly in cultured skin fibroblasts from patients with AICA-ribosiduria and ADSL deficiency. Hum Mol Genet. 2011 Dec 30. [Epub ahead of print] PubMed PMID: 22180458.

Bartley MG, Marquardt K, Kirchhof D, Wilkins HM, Patterson D, Linseman DA.Overexpression of Amyloid-β Protein Precursor Induces Mitochondrial OxidativeStress and Activates the Intrinsic Apoptotic Cascade. J Alzheimers Dis. 2011 Dec 1. [Epub ahead of print] PubMed PMID: 22133762.

Patterson D, Cabelof DC. Down syndrome as a model of DNA polymerase betahaploinsufficiency and accelerated aging. Mech Ageing Dev. 2011 Oct 12. [Epubahead of print] PubMed PMID: 22019846.

Vliet LK, Wilkinson TG 2nd, Duval N, Vacano G, Graham C, Zikánová M, SkopovaV, Baresova V, Hnízda A, Kmoch S, Patterson D. Molecular characterization of the AdeI mutant of Chinese hamster ovary cells: a cellular model of adenylosuccinate lyase deficiency. Mol Genet Metab. 2011 Jan;102(1):61-8. Epub 2010 Sep 6. PubMed PMID: 20884265; PubMed Central PMCID: PMC3065963.

Maclean KN, Sikora J, Kožich V, Jiang H, Greiner LS, Kraus E, Krijt J,Overdier KH, Collard R, Brodsky GL, Meltesen L, Crnic LS, Allen RH, Stabler SP,Elleder M, Rozen R, Patterson D, Kraus JP. A novel transgenic mouse model ofCBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis andexhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.Mol Genet Metab. 2010 Oct-Nov;101(2-3):153-62. Epub 2010 Jun 23. PubMed PMID:20638879; PubMed Central PMCID: PMC2954364.

Patterson D. Molecular genetic analysis of Down syndrome. Hum Genet. 2009Jul;126(1):195-214. Epub 2009 Jun 13. Review. PubMed PMID: 19526251.

Patterson D. Folate metabolism and the risk of Down syndrome. Downs Syndr Res Pract. 2008 Oct;12(2):93-7. Review. PubMed PMID: 19026278.

Yu J, Zhang Y, Qi Z, Kurtycz D, Vacano G, Patterson D. Methylation-mediateddownregulation of the B-cell translocation gene 3 (BTG3) in breast cancer cells. Gene Expr. 2008;14(3):173-82. PubMed PMID: 18590053.

Pritchard M, Reeves RH, Dierssen M, Patterson D, Gardiner KJ. Down syndromeand the genes of human chromosome 21: current knowledge and future potentials.Report on the Expert workshop on the biology of chromosome 21 genes: towardsgene-phenotype correlations in Down syndrome. Washington D.C., September28-October 1, 2007. Cytogenet Genome Res. 2008;121(1):67-77. Epub 2008 May 7.PubMed PMID: 18544929.

Marshall LJ, Moore AC, Ohki M, Kitabayashi I, Patterson D, Ornelles DA. RUNX1permits E4orf6-directed nuclear localization of the adenovirus E1B-55K proteinand associates with centers of viral DNA and RNA synthesis. J Virol. 2008Jul;82(13):6395-408. Epub 2008 Apr 16. PubMed PMID: 18417565; PubMed CentralPMCID: PMC2447068.

Hunsucker SW, Solomon B, Gawryluk J, Geiger JD, Vacano GN, Duncan MW,Patterson D. Assessment of post-mortem-induced changes to the mouse brainproteome. J Neurochem. 2008 May;105(3):725-37. Epub 2007 Dec 12. PubMed PMID:18088372.

Patterson D, Graham C, Cherian C, Matherly LH. A humanized mouse model forthe reduced folate carrier. Mol Genet Metab. 2008 Feb;93(2):95-103. Epub 2007 Nov5. PubMed PMID: 17983788; PubMed Central PMCID: PMC2271060.

Lott IT, Patterson D, Seltzer MM. Toward a research agenda for Down syndrome.Ment Retard Dev Disabil Res Rev. 2007;13(3):288-9. PubMed PMID: 17910088.

Patterson D. Genetic mechanisms involved in the phenotype of Down syndrome.Ment Retard Dev Disabil Res Rev. 2007;13(3):199-206. Review. PubMed PMID:17910086.

Head E, Lott IT, Patterson D, Doran E, Haier RJ. Possible compensatory eventsin adult Down syndrome brain prior to the development of Alzheimer diseaseneuropathology: targets for nonpharmacological intervention. J Alzheimers Dis.2007 Mar;11(1):61-76. Review. PubMed PMID: 17361036.

Scott Pegan

Connor SE, Capodagli GC, Deaton MK, Pegan SD. Structural and functional characterization of Mycobacterium tuberculosis triosephosphate isomerase. Acta Crystallogr D Biol Crystallogr. 2011 Dec;67(Pt 12):1017-22. Epub 2011 Nov 5. PubMed PMID: 22120738.

Park SK, Pegan SD, Mesecar AD, Jungbauer LM, LaDu MJ, Liebman SW. Development and validation of a yeast high-throughput screen for inhibitors of Aβ₄₂ oligomerization. Dis Model Mech. 2011 Nov;4(6):822-31. Epub 2011 Aug 2. PubMed PMID: 21810907; PubMed Central PMCID: PMC3209651.

Pegan SD, Sturdy M, Ferry G, Delagrange P, Boutin JA, Mesecar AD. X-ray structural studies of quinone reductase 2 nanomolar range inhibitors. Protein Sci. 2011 Jul;20(7):1182-95. doi: 10.1002/pro.647. Epub 2011 May 23. PubMed PMID: 21538647; PubMed Central PMCID: PMC3149192.

Capodagli GC, McKercher MA, Baker EA, Masters EM, Brunzelle JS, Pegan SD. Structural analysis of a viral ovarian tumor domain protease from the Crimean-Congo hemorrhagic fever virus in complex with covalently bonded ubiquitin. J Virol. 2011 Apr;85(7):3621-30. Epub 2011 Jan 12. PubMed PMID: 21228232; PubMed Central PMCID: PMC3067871.

Burks EA, Fleming CD, Mesecar AD, Whitman CP, Pegan SD. Kinetic and structural characterization of a heterohexamer 4-oxalocrotonate tautomerase from Chloroflexus aurantiacus J-10-fl: implications for functional and structural diversity in the tautomerase superfamily . Biochemistry. 2010 Jun 22;49(24):5016-27. PubMed PMID: 20465238; PubMed Central PMCID: PMC2913408.

Pegan SD, Tian Y, Sershon V, Mesecar AD. A universal, fully automated high throughput screening assay for pyrophosphate and phosphate release from enzymatic reactions. Comb Chem High Throughput Screen. 2010 Jan;13(1):27-38. PubMed PMID: 20201823.

Mo S, Krunic A, Pegan SD, Franzblau SG, Orjala J. An antimicrobial guanidine-bearing sesterterpene from the cultured cyanobacterium Scytonema sp. J Nat Prod. 2009 Nov;72(11):2043-5. PubMed PMID: 19888742; PubMed Central PMCID: PMC2988765.

Guo S, Tipparaju SK, Pegan SD, Wan B, Mo S, Orjala J, Mesecar AD, Franzblau SG, Kozikowski AP. Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents. Bioorg Med Chem. 2009 Oct 15;17(20):7126-30. Epub 2009 Sep 4. PubMed PMID: 19783449; PubMed Central PMCID: PMC2983099.

Maiti A, Reddy PV, Sturdy M, Marler L, Pegan SD, Mesecar AD, Pezzuto JM, Cushman M. Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. J Med Chem. 2009 Apr 9;52(7):1873-84. PubMed PMID: 19265439; PubMed Central PMCID: PMC2673050.

Pegan SD, Rukseree K, Franzblau SG, Mesecar AD. Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. J Mol Biol. 2009 Mar 6;386(4):1038-53. Epub 2009 Jan 10. PubMed PMID: 19167403; PubMed Central PMCID: PMC2654403.

Pegan SD, Serrano H, Whitman CP, Mesecar AD. Structural and mechanistic analysis of trans-3-chloroacrylic acid dehalogenase activity. Acta Crystallogr D Biol Crystallogr. 2008 Dec;64(Pt 12):1277-82. Epub 2008 Nov 18. PubMed PMID: 19018104; PubMed Central PMCID: PMC2631126.