Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease
Dr. James Fogleman has recently joined the Eleanor Roosevelt Institute's research program focusing on ALS (amyotrophic lateral sclerosis or Lou Gehrig's disease), a fatal neurodegenerative disease characterized by progressive paralysis.
ALS is known to have both sporadic and familial forms. Mutations in the copper-zinc superoxide dismutase gene (SOD1) account for 10 to 20 percent of the inherited ALS. Over 100 different mutations in the SOD1 gene can cause ALS in humans and at least eight of these have been shown to produce an ALS-like phenotype when expressed in transgenic mice.