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Selected publications from ERI affiliated faculty

Joseph Angleson, Ph.D.

Veo K, Reinick C, Liang L, Moser E,Angelson JK, Dores RM. Observations on the ligand selectivity of the melanocortin 2 receptor. Gen Comp Endocrinol. 2011 May 15;172(1):3-9. Epub 2011 Apr 8. Review. PubMed PMID: 21501611.

Chen Q, Layton K, Veo K,Angelson JK, Dores RM. α-TC1.9 cells--a model system for analyzing the endoproteolytic processing of POMC. Gen Comp Endocrinol. 2011 May 15;172(1):96-106. Epub 2011 Jan 4. PubMed PMID: 21211538.

Sadler SE,Angelson JK, Dsouza M. IGF-1 receptors in Xenopus laevis ovarian follicle cells support the oocyte maturation response. Biol Reprod. 2010 Mar;82(3):591-8. Epub 2009 Nov 18. PubMed PMID: 19923252.

Overlease RL, Bauer RA, Angleson JK (2005). Retention of peptide hormone during partial secretion in pituitary somatotrophs and corticotrophs. Eur J Physiol (Pfluger's Arch) 449, 458-62

Bauer RA, Overlease RL, Lieber JL, Angleson JK (2004). Retention and stimulus-dependent recycling of dense core vesicle content in neuroendocrine cells. J of Cell Sci 117, 2193-2202

Bauer RA, Khera RS, Lieber JL, Angleson JK (2004). Recycling of intact dense core vesicles in neurites of NGF-treated PC12 cells. FEBS Lett 571, 107-111

Vo YP, Hutton JC, Angleson JK (2004). Recycling of the dense-core vesicle membrane protein phogrin in Min6 beta-cells. Biochem Biophy Res Com 324, 1004-1010

Zahn TR, Angleson JK, MacMorris MA, Domke1 E, Hutton JF, Schwartz C, Hutton JC (2004). Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104. Traffic 5, 544-559

Wan Y, Angleson JK, Kutateladze AG (2002). Liposomes from novel photolabile phospholipids: light-induced unloading of small molecules as monitored by PFG NMR. J Am Chem Soc 124, 5610-5611

Angleson JK, Betz WJ (2001). Intraterminal Ca2+ and spontaneous transmitter release at the frog neuromuscular junction. J Neurophysiol 85, 287-294

Kilic G, Angleson JK, Cochilla AJ, Nussinovitch I, Betz WJ (2001). Sustained stimulation of exocytosis triggers continuous membrane retrieval in rat pituitary somatotrophs. J Physiol 532, 771-783.

Cochilla AJ, Angleson JK, Betz WJ (2000). Differential regulation of granule-to-granule and granule-to-plasma membrane fusion during secretion from rat pituitary lactotrophs. J Cell Biol 150, 839-8348

Angleson JK, Cochilla AJ, Kilic G, Nussinovitch I, Betz WJ (1999). Regulation of dense core release from neuroendocrine cells revealed by imaging single events. Nature Neuroscience 2, 440-446

Cochilla AJ, Angleson JK, Betz WJ (1999). Monitoring secretory membrane with FM1-43 fluorescence. Ann Rev Neurosci 22, 1-10

Betz WJ, Angleson JK (1997). Cellular secretion: Now you see it, now you don't. Nature 388, 423-424

Scott Barbee, Ph.D.

Hillebrand J, Pan K, Kokaram A, Barbee S, Parker R and Ramaswami M (2010). The Me31B DEAD-box helicase localizes to postsynaptic foci and regulates expression of a CaMKII reporter mRNA in dendrites of Drosophila olfactory projection neurons. Front. Neural Circuits 4:121.

Cziko A-M, McCann CT, Howlett IC, Barbee SA, Duncan R, Luedemann R, Zarnescu D, Zinsmaier KE, Parker RR, Ramaswami M (2009). Genetic modifiers of dFMR1 encode RNA granule components in Drosophila. Genetics 182(4):1051-1060.

Kwak JE, Drier E, Barbee SA, Ramaswami M, Yin JCP, Wickens M (2008). GLD2 poly(A) polymerase is specifically required for long-term memory. PNAS. 105(38):14644-14649.

Satterlee J, Barbee S, Jin P, Krichevsky A, Salama S, Schratt G, Wu D-Y (2007). Non-coding RNAs in the brain. J Neurosci. 27(44)11856-9.

Hillebrand J*, Barbee SA*, Ramaswami M (2007). P-body components, microRNA regulation, and synaptic plasticity. ScientificWorldJournal. 7:178-90. * Co-first authors.

Barbee SA, Estes PS, Cziko A-M, Hillebrand J, Luedeman RA, Coller JM, Johnson N, Howlett IC, Geng C, Ueda R, Brand AH, Newbury SF, Wilhelm JE, Levine RB, Nakamura A, Parker R, Ramaswami M (2006). Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P-bodies. Neuron 52(6):997-1009.

Barbee SA, Evans TC (2006). The Sm proteins regulate germ cell specification during early C. elegans embryogenesis. Dev. Biol. 2006 291(1):132-143.

Barbee SA, Lublin AL, Evans TC. A novel function for the Sm proteins in germ granule localization during C. elegans embryogenesis. Curr Biol. 12(17):1502-1506.

Patrick Bosque, M.D.

Bosque PJ, Tyler KL. Prions' travels--feces and transmission of prion diseases. J Infect Dis. 2008 Jul 1;198(1):8-9. PubMed PMID: 18505382.

Anderson CA, Bosque P, Filley CM, Arciniegas DB, Kleinschmidt-DeMasters BK Pape J, Tyler, KL (2007). Lessons from the Colorado Surveillance Program for Chronic Wasting Disease Transmission to Humans: two highly suspicious but negative cases. Arch Neurol 64, 439-441

Tamguney E, Giles K, Bouszmondo-Bernstein E, Bosque P, Safar J, DeArmond S, Miller M, Prusiner S (2006). Transmission of elk and deer prions to transgenic mice. J Virol 80, 9104-9114

MaWhinney S, Pape WJ, Forster JE, Anderson CA, Bosque P, Miller MW. Human prion disease and relative risk associated with chronic wasting disease (2006). Emerg Infect Dis [serial on the Internet]. Available from http://www.cdc.gov/ncidod/EID/vol12no10/06-0019.htm

Bosque P (2005). Molecular types of Creutzfeldt-Jakob disease: the strange diversity of prions. Neurology 65, 1520-1521

Gonzales N, Jarboe E, Kleinschmidt-DeMasters B, Bosque P (2005). Acute multifocal CNS demyelination as first presentation of systemic malignancy. Neurology 65, 166

Hall DA, Leehey MA, Filley CM, Steinbart E, Montine T, Schellenberg GD, Bosque P, Nixon R, Bird T (2005). PRNP H187R mutation associated with neuropsychiatric disorders in childhood and dementia. Neurology 64, 1304-1306 Bosque P (2004). Double blind trial of flupirtine in cretuzfeldt-Jakob disease. (editorial) Neurology 65, 679

Bosque PJ, Ryou C, Telling G, Peretz D, Legname G, DeArmond SJ, Prusiner SB (2002). Prions in skeletal muscle. Proc Natl Acad Sci U S A 99, 3812-3817 Bosque P (2002). Bovine spongiform encephalopathy, chronic wasting disease, scrapie, and the threat to humans from prion disease epizootics. Current Neurology and Neuroscience Reports 2, 488-495

Phillip B. Danielson, Ph.D.

Komorowski LK, Lecaude SG, Westring CG, Danielson PB, Dores RM. Evolution of gnathostome prodynorphin and proenkephalin: Characterization of a shark proenkephalin and prodynorphin cDNAs. Gen Comp Endocrinol. 2011 Dec 22. [Epub ahead of print] PubMed PMID: 22210245.

Kristinsson R, Lewis SE, Danielson PB. Comparative analysis of the HV1 and HV2 regions of human mitochondrial DNA by denaturing high-performance liquid chromatography. J Forensic Sci. 2009 Jan;54(1):28-36. PubMed PMID: 19120825.

Danielson PB, Hong-Yu Sun H-Y, Melton T, Kristinsson, A (2007). Resolving mtDNA mixtures by denaturing high-performance liquid chromatography and linkage phase determination Forensic Science International: Genetics 1, 148-153

Westring CG, Kristinsson R, M.S. Gilbert DS, Danielson PB (2007). Validation of reduced-scale reactions for the quantifilerTM human DNA kit J Forensic Sci 52, 1035-1043

Danielson PB, Kristinsson R, Shelton RJ, LaBerge GS (2005). Separating human DNA mixtures using denaturing high-performance liquid chromatography Expert Rev Mol Diagn 5(1), 53-63

Danielson PB (2002). The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans Current Drug Metabolism 3, 561-597

James C. Fogleman, Ph.D.

Fogleman JC, Trilk S, Yackley A, Westring C, Forbes S, Lumsden T, Kunst CB (2011)  Fine Mapping of an Amyotrophic Lateral Sclerosis Modifier Locus to a Single BAC. WebmedCentral GENETICS;2(7):WMC002044

Fogleman JC (2000). Response of Drosophila melanogaster to selection for P450-mediated resistance to isoquinoline alkaloids. Chem Biol Interact 125, 93-105

Danielson PB, Foster JL, McMahill MM, Smith MK, Fogleman JC (1998). Induction by alkaloids and phenobarbital of Family 4 Cytochrome P450s in Drosophila: evidence for involvement in host plant utilization. Mol Gen Genet 259, 54-59

Fogleman JC, Danielson PB, Frank MR (1997). Comparison of Drosophila cytochrome P450 metabolism of natural and model substrates. J Insect Physiol 43, 953-957

Danielson PB, MacIntyre RJ, Fogleman JC (1997). Molecular cloning of a family of xenobiotic-inducible drosophilid cytochrome p450s: evidence for involvement in host-plant allelochemical resistance. Proc Natl Acad Sci U S A 94, 10797-10802

Danielson PB, Fogleman JC (1997). Isolation and sequence analysis of cytochrome P450 12B1: the first mitochondrial insect P450 with homology to 1 alpha, 25 dihydroxy-D3 24-hydroxylase. Insect Biochem Mol Biol 27, 595-604 Daniel A. Linseman Ph.D.

Kingshuk Ghosh

Evidence of Multiple Folding Pathways for the Villin Headpiece Subdomain. L. Zhu, K. Ghosh, M. King, T. Cellmer, O. Bakajin and L.J. Lapidus J. Phys. Chem B. 115 12632-12637 (2011)

Physical limits of cells and proteomes. K.A. Dill, K. Ghosh and J.D. Schmit Proc. Natl. Acad. Sci. 108, 17876-17882 (2011).

How do thermophilic proteins and proteomes withstand high temperature? L. Sawle, K. Ghosh Biophysical Journal 101 (2011).

Stochastic dynamics of complexation reaction in the limit of small numbers. K. Ghosh J. Chem. Phys. 134, 195101 (2011) (selected in the June 1, 2011 issue of Virtual Journal of Biological Physics Research from AIP and APS)

Modeling stochastic dynamics in biochemical systems with feedback using Maximum Caliber. S. Presse, K. Ghosh and K.A. Dill J Phys. Chem. B 115 6202 (2011).

What Drives Amyloid Molecules To Assemble into Oligomers and Fibrils? J. D. Schmit, K. Ghosh and K. A. Dill Biophysical Journal 100, 450 (2011).

Cellular proteomes have broad distributions of protein stability. K. Ghosh and K.A. Dill Biophysical Journal 99, 3996-4002 (2010).

Dynamical fluctuations in biochemical reactions and cycles. S. Presse, K. Ghosh, R. Phillips and K. A. Dill. Phys Rev E 82, 031905 (2010).

Trajectory approach to two-state kinetics of single particles on sculpted energy landscapes. D. Wu, K. Ghosh, M. Inamdar, H. J. Lee, S. Fraser, K. A. Dill and R. Phillips. Phys. Rev. Lett. 103, 050603 (2009).

Computing protein stabilities from their chain lengths K. Ghosh and K. A. Dill. Proc. Natl. Acad. Sci. 106(26), 10649-10654 (2009).

Theory for protein folding cooperativity: helix-bundles. K. Ghosh and K. A. Dill, J. Am. Chem. Soc., 131(6), 2306 (2009).

Maximum caliber: A variational approach applied to two-state dynamics. G. Stock, K. Ghosh and Ken. A. Dill, to appear in J. Chem Phys., 128, 194102 (2008).

The ultimate speed limit to protein folding is conformational searching. K. Ghosh, S. B. Ozkan and K. A. Dill, J. Am. Chem. Soc., 129, 11920 (2007)

Measuring Flux Distribution in the Small-Numbers Limit. E. Seitaridou, M. M. Inamdar, R. Phillips, K. Ghosh, K. A. Dill, J. Phys. Chem B, 111, 2288 (2007).

Teaching the Principles of Statistical Dynamics. K. Ghosh, K. Dill, M. N. Inamdar, E. Seitaridou and R. Phillips, Am. J. Phys., 74, 123-133 (2006).

Daniel Linseman, Ph.D.

Bartley MG, Marquardt K, Kirchhof D, Wilkins HM, Patterson D, Linseman DA. Overexpression of Amyloid-β Protein Precursor Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptotic Cascade. J Alzheimers Dis. 2011 Dec 1. [Epub ahead of print] PubMed PMID: 22133762.

Wilkins HM, Marquardt K, Lash LH, Linseman DA. Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione. Free Radic Biol Med. 2011 Nov 9. [Epub ahead of print] PubMed PMID: 22115789.

Kelsey NA, Wilkins HM, Linseman DA. Nutraceutical antioxidants as novel neuroprotective agents. Molecules. 2010 Nov 3;15(11):7792-814. Review. PubMed PMID: 21060289.

Harbison RA, Ryan KR, Wilkins HM, Schroeder EK, Loucks FA, Bouchard RJ, Linseman DA. Calpain plays a central role in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in cerebellar granule neurons. Neurotox Res. 2011 Apr;19(3):374-88. Epub 2010 Mar 24. PubMed PMID: 20333497.

Loucks FA, Schroeder EK, Zommer AE, Hilger S, Kelsey NA, Bouchard RJ, Blackstone C, Brewster JL, Linseman DA. Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis. Brain Res. 2009 Jan 23;1250:63-74. Epub 2008 Nov 18. PubMed PMID: 19046944; PubMed Central PMCID: PMC2771186.

Schroeder EK, Kelsey NA, Doyle J, Breed E, Bouchard RJ, Loucks FA, Harbison RA, Linseman DA. Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons. Antioxid Redox Signal. 2009 Mar;11(3):469-80. PubMed PMID: 18754708.

Linseman DA. Targeting oxidative stress for neuroprotection. Antioxid Redox Signal. 2009 Mar;11(3):421-4. PubMed PMID: 18715147.

Linseman DA, Loucks FA (2008). Diverse roles of Rho family GTPases in neuronal development, survival, and death. Front Biosci 13, 657-676

Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, and Linseman DA (2007). Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria. J Biol Chem 282, 29296-29304

Loucks FA, Le SS, Zimmermann AK, Ryan KR, Barth H, Aktories K, Linseman DA (2006). Rho family GTPase inhibition reveals opposing effects of MEK/ERK and JAK/STAT signaling cascades on neuronal survival. J Neurochem 97, 957-967

Brewster JL, Linseman DA, Bouchard RJ, Loucks FA, Esche EA, Precht TA, Heidenreich KA (2006). Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3beta and a caspase-9-dependent apoptosis in cerebellar granule neurons. Mol Cell Neurosci 32, 242-253

Le SS, Loucks FA, Udo H, Richardson-Burns S, Phelps RA, Bouchard RJ, Barth H, Aktories K, Tyler KL, Kandel ER, Heidenreich KA, Linseman DA (2005). Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons. J Neurochem 94, 1025-1039

Zimmermann AK, Loucks FA, Le SS, Butts BD, Florez-McClure ML, Bouchard RJ, Heidenreich KA, Linseman DA (2005). Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim. J Neurochem 94, 22-36

Precht TA, Phelps RA, Linseman DA, Butts BD, Le SS, Laessig TA, Bouchard RJ, Heidenreich KA (2005). The permeability transition pore triggers Bax translocation to mitochondria during neuronal apoptosis. Cell Death Differ 12, 255-265

Linseman DA, Butts BD, Precht TA, Phelps RA, Le SS, Laessig TA, Bouchard RJ, Florez-McClure ML, Heidenreich KA (2004). Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J Neurosci 24, 9993-10002

Ahmadi F, Linseman DA, Grammatopoulos TN, Jones SM, Bouchard RJ, Freed CR, Heidenreich KA, Zawada WM (2003). The pesticide rotenone induces caspase-3- mediated apoptosis in ventral mesencephalic dopaminergic neurons. J Neurochem 87, 914-921

Linseman DA, Phelps RA, Bouchard RJ, Le SS, Laessig TA, McClure ML, Heidenreich KA (2002). Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons. J Neurosci 22, 9287-9297

Linseman DA, McClure ML, Bouchard RJ, Laessig TA, Ahmadi FA, Heidenreich KA (2002). Suppression of death receptor signaling in cerebellar Purkinje neurons protects neighboring granule neurons from apoptosis via an insulin-like growth factor-I- dependent mechanism. J Biol Chem 277, 24546-24553

Nancy M. Lorenzon, Ph.D.

Lorenzon NM, Beam KG (2008). Disease causing mutations of calcium channels. Channels 2:3, 1-17, in press, May/June

Lorenzon NM, Beam KG (2007). Accessibility of targeted DHPR sites to streptavidin and functional effects of binding on EC coupling. J Gen Physiol 130, 379-388

Lorenzon NM, Haarmann CS, Norris EE, Papadopoulos S, Beam KG (2004). Metabolic biotinylation as a probe of supramolecular structure of the triad junction in skeletal muscle. J Biol Chem 279, 44057-44064

Lorenzon NM, Beam KG (2000). Calcium channelopathies. Kidney Int 57, 794-802

Foehring RC, Lorenzon NM (1999). Neuromodulation, development and synaptic plasticity. Can J Exp Psychol 53, 45-61

Lorenzon NM, Lutz CM, Frankel WN, Beam KG (1998). Altered calcium channel currents in Purkinje cells of the neurological mutant mouse leaner. J Neurosci 18, 4482-4489

Lorenzon NM, Foehring RC (1995). Alterations in intracellular calcium chelation reproduce developmental differences in repetitive firing and after hyperpolarizations in rat neocortical neurons. Brain Res Dev Brain Res 84, 192-203

Lorenzon NM, Foehring RC (1995). Characterization of pharmacologically identified voltage-gated calcium channel currents in acutely isolated rat neocortical neurons. II. Postnatal development. J Neurophysiol 73, 1443-1451

Martin M. Margittai, Ph.D.

Dinkel PD, Siddiqua A, Huynh H, Shah M, Margittai M. Variations in filament conformation dictate seeding barrier between three- and four-repeat tau. Biochemistry. 2011 May 24;50(20):4330-6. Epub 2011 May 2. PubMed PMID: 21510682.

Siddiqua A, Margittai M. Three- and four-repeat Tau coassemble into heterogeneous filaments: an implication for Alzheimer disease. J Biol Chem. 2010 Nov 26;285(48):37920-6. Epub 2010 Oct 4. PubMed PMID: 20921227; PubMed Central PMCID: PMC2988394.

Margittai M, Langen R. Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy. Q Rev Biophys. 2008 Aug-Nov;41(3-4):265-97. Review. PubMed PMID: 19079806.

Chen M, Margittai M, Chen J, Langen R (2007). Investigation of alpha-synuclein fibril structure by site-directed spin labeling. J Biol Chem 282, 24970-24979 Margittai M, Langen R (2006). Spin labeling analysis of amyloids and other protein aggregates. Methods Enzymol 413, 122-139

Margittai M, Langen R (2006). Side chain-dependent stacking modulates tau filament structure. J Biol Chem 281, 37820-37827

Margittai M, Langen R (2004). Template-assisted filament growth by parallel stacking of tau. Proc Natl Acad Sci U S A 101, 10278-10283

Schuette CG, Hatsuzawa K, Margittai M, Stein A, Riedel D, Küster P, König M, Seidel C, Jahn R (2004). Determinants of liposome fusion mediated by synaptic SNARE proteins. Proc Natl Acad Sci U S A 101, 2858-2863 Margittai M, Widengren J, Schweinberger E, Schröder GF, Felekyan S, Haustein E, König M, Fasshauer D, Grubmüller H, Jahn R, Seidel CA (2003). Single-molecule fluorescence resonance energy transfer reveals a dynamic equilibrium between closed and open conformations of syntaxin 1. Proc Natl Acad Sci U S A 100, 15516-15521 Fasshauer D, Margittai M (2004). A transient N-terminal interaction of SNAP-25 and syntaxin nucleates SNARE assembly. J Biol Chem 279, 7613-7621 Margittai M, Fasshauer D, Jahn R, Langen R (2003). The Habc domain and the SNARE core complex are connected by a highly flexible linker. Biochemistry 42, 4009-4014

David Patterson, Ph.D.

Baresova V, Skopova V, Sikora J, Patterson D, Sovova J, Zikanova M, Kmoch S. Mutations of ATIC and ADSL affect purinosome assembly in cultured skin fibroblasts from patients with AICA-ribosiduria and ADSL deficiency. Hum Mol Genet. 2011 Dec 30. [Epub ahead of print] PubMed PMID: 22180458.

Bartley MG, Marquardt K, Kirchhof D, Wilkins HM, Patterson D, Linseman DA.Overexpression of Amyloid-β Protein Precursor Induces Mitochondrial OxidativeStress and Activates the Intrinsic Apoptotic Cascade. J Alzheimers Dis. 2011 Dec 1. [Epub ahead of print] PubMed PMID: 22133762.

Patterson D, Cabelof DC. Down syndrome as a model of DNA polymerase betahaploinsufficiency and accelerated aging. Mech Ageing Dev. 2011 Oct 12. [Epubahead of print] PubMed PMID: 22019846.

Vliet LK, Wilkinson TG 2nd, Duval N, Vacano G, Graham C, Zikánová M, SkopovaV, Baresova V, Hnízda A, Kmoch S, Patterson D. Molecular characterization of the AdeI mutant of Chinese hamster ovary cells: a cellular model of adenylosuccinate lyase deficiency. Mol Genet Metab. 2011 Jan;102(1):61-8. Epub 2010 Sep 6. PubMed PMID: 20884265; PubMed Central PMCID: PMC3065963.

Maclean KN, Sikora J, Kožich V, Jiang H, Greiner LS, Kraus E, Krijt J,Overdier KH, Collard R, Brodsky GL, Meltesen L, Crnic LS, Allen RH, Stabler SP,Elleder M, Rozen R, Patterson D, Kraus JP. A novel transgenic mouse model ofCBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis andexhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.Mol Genet Metab. 2010 Oct-Nov;101(2-3):153-62. Epub 2010 Jun 23. PubMed PMID:20638879; PubMed Central PMCID: PMC2954364.

Patterson D. Molecular genetic analysis of Down syndrome. Hum Genet. 2009Jul;126(1):195-214. Epub 2009 Jun 13. Review. PubMed PMID: 19526251.

Patterson D. Folate metabolism and the risk of Down syndrome. Downs Syndr Res Pract. 2008 Oct;12(2):93-7. Review. PubMed PMID: 19026278.

Knox AJ, Graham C, Bleskan J, Brodsky G, Patterson D. Mutations in the Chinesehamster ovary cell GART gene of de novo purine synthesis. Gene. 2009 Jan15;429(1-2):23-30. Epub 2008 Oct 21. PubMed PMID: 19007868; PubMed Central PMCID:PMC2643067.

Yu J, Zhang Y, Qi Z, Kurtycz D, Vacano G, Patterson D. Methylation-mediateddownregulation of the B-cell translocation gene 3 (BTG3) in breast cancer cells. Gene Expr. 2008;14(3):173-82. PubMed PMID: 18590053.

Pritchard M, Reeves RH, Dierssen M, Patterson D, Gardiner KJ. Down syndromeand the genes of human chromosome 21: current knowledge and future potentials.Report on the Expert workshop on the biology of chromosome 21 genes: towardsgene-phenotype correlations in Down syndrome. Washington D.C., September28-October 1, 2007. Cytogenet Genome Res. 2008;121(1):67-77. Epub 2008 May 7.PubMed PMID: 18544929.

Marshall LJ, Moore AC, Ohki M, Kitabayashi I, Patterson D, Ornelles DA. RUNX1permits E4orf6-directed nuclear localization of the adenovirus E1B-55K proteinand associates with centers of viral DNA and RNA synthesis. J Virol. 2008Jul;82(13):6395-408. Epub 2008 Apr 16. PubMed PMID: 18417565; PubMed CentralPMCID: PMC2447068.

Hunsucker SW, Solomon B, Gawryluk J, Geiger JD, Vacano GN, Duncan MW,Patterson D. Assessment of post-mortem-induced changes to the mouse brainproteome. J Neurochem. 2008 May;105(3):725-37. Epub 2007 Dec 12. PubMed PMID:18088372.

Patterson D, Graham C, Cherian C, Matherly LH. A humanized mouse model forthe reduced folate carrier. Mol Genet Metab. 2008 Feb;93(2):95-103. Epub 2007 Nov5. PubMed PMID: 17983788; PubMed Central PMCID: PMC2271060.

Lott IT, Patterson D, Seltzer MM. Toward a research agenda for Down syndrome.Ment Retard Dev Disabil Res Rev. 2007;13(3):288-9. PubMed PMID: 17910088.

Patterson D. Genetic mechanisms involved in the phenotype of Down syndrome.Ment Retard Dev Disabil Res Rev. 2007;13(3):199-206. Review. PubMed PMID:17910086.

Head E, Lott IT, Patterson D, Doran E, Haier RJ. Possible compensatory eventsin adult Down syndrome brain prior to the development of Alzheimer diseaseneuropathology: targets for nonpharmacological intervention. J Alzheimers Dis.2007 Mar;11(1):61-76. Review. PubMed PMID: 17361036.

Lynn M. Taussig, M.D.

Zeiger RS, Mauger D, Bacharier LB, Guilbert TW, Martinez FD, Lemanske RF Jr, Strunk RC, Covar R, Szefler SJ, Boehmer S, Jackson DJ, Sorkness CA, Gern JE, Kelly HW, Friedman NJ, Mellon MH, Schatz M, Morgan WJ, Chinchilli VM, Raissy HH, Bade E, Malka-Rais J, Beigelman A, Taussig LM; CARE Network of the National Heart, Lung, and Blood Institute. Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med. 2011 Nov 24;365(21):1990-2001. PubMed PMID: 22111718; PubMed Central PMCID: PMC3247621.

Horner CC, Mauger D, Strunk RC, Graber NJ, Lemanske RF Jr, Sorkness CA, Szefler SJ, Zeiger RS, Taussig LM, Bacharier LB; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Most nocturnal asthma symptoms occur outside of exacerbations and associate with morbidity. J Allergy Clin Immunol. 2011 Nov;128(5):977-82.e1-2. Epub 2011 Sep 8. PubMed PMID: 21855126.

Guilbert TW, Mauger DT, Allen DB, Zeiger RS, Lemanske RF Jr, Szefler SJ, Strunk RC, Bacharier LB, Covar R, Sorkness CA, Taussig LM, Martinez FD; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone. J Allergy Clin Immunol. 2011 Nov;128(5):956-63.e1-7. Epub 2011 Aug 4. PubMed PMID: 21820163; PubMed Central PMCID: PMC3224818.

Wang L, Hollenbeak CS, Mauger DT, Zeiger RS, Paul IM, Sorkness CA, Lemanske RF Jr, Martinez FD, Strunk RC, Szefler SJ, Taussig LM; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Cost-effectiveness analysis of fluticasone versus montelukast in children with mild-to-moderate persistent asthma in the Pediatric Asthma Controller Trial. J Allergy Clin Immunol. 2011 Jan;127(1):161-6, 166.e1. PubMed PMID: 21211651; PubMed Central PMCID: PMC3061816.

Lemanske RF Jr, Mauger DT, Sorkness CA, Jackson DJ, Boehmer SJ, Martinez FD, Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, Covar RA, Guilbert TW, Larsen G, Morgan WJ, Moss MH, Spahn JD, Taussig LM; Childhood Asthma Research and Education (CARE) Network of the National Heart, Lung, and Blood Institute. Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids. N Engl J Med. 2010 Mar 18;362(11):975-85. Epub 2010 Mar 2. PubMed PMID: 20197425; PubMed Central PMCID: PMC2989902.

Beigelman A, Mauger DT, Phillips BR, Zeiger RS, Taussig LM, Strunk RC, Bacharier LB; Childhood Asthma Research and Education (CARE) Network; National Heart, Lung and Blood Institute. Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing. Ann Allergy Asthma Immunol. 2009 Aug;103(2):108-13. PubMed PMID: 19739422.

Paul IM, Camera L, Zeiger RS, Guilbert TW, Bacharier LB, Taussig LM, Morgan WJ, Covar RA, Krawiec M, Bloomberg GR, Mauger DT; Childhood Asthma Research and Education (CARE) Network. Relationship between infant weight gain and later asthma. Pediatr Allergy Immunol. 2010 Feb;21(1 Pt 1):82-9. Epub 2009 Aug 27. PubMed PMID: 19725894; PubMed Central PMCID: PMC2887600.

Rivera-Spoljaric K, Chinchilli VM, Camera LJ, Zeiger RS, Paul IM, Phillips BR, Taussig LM, Strunk RC, Bacharier LB; Childhood Asthma Research and Education (CARE) Network. Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezing. J Pediatr. 2009 Jun;154(6):877-81.e4. Epub 2009 Mar 25. PubMed PMID: 19324370; PubMed Central PMCID: PMC3086348.

Bacharier LB, Guilbert TW, Zeiger RS, Strunk RC, Morgan WJ, Lemanske RF Jr, Moss M, Szefler SJ, Krawiec M, Boehmer S, Mauger D, Taussig LM, Martinez FD; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Patient characteristics associated with improved outcomes with use of an inhaled corticosteroid in preschool children at risk for asthma. J Allergy Clin Immunol. 2009 May;123(5):1077-82, 1082.e1-5. Epub 2009 Feb 23. PubMed PMID: 19230959; PubMed Central PMCID: PMC2909590.

Knuffman JE, Sorkness CA, Lemanske RF Jr, Mauger DT, Boehmer SJ, Martinez FD, Bacharier LB, Strunk RC, Szefler SJ, Zeiger RS, Taussig LM; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Phenotypic predictors of long-term response to inhaled corticosteroid and leukotriene modifier therapies in pediatric asthma. J Allergy Clin Immunol. 2009 Feb;123(2):411-6. Epub 2009 Jan 3. PubMed PMID: 19121860; PubMed Central PMCID: PMC2662352.

Larsen GL, Morgan W, Heldt GP, Mauger DT, Boehmer SJ, Chinchilli VM, Lemanske RF Jr, Martinez F, Strunk RC, Szefler SJ, Zeiger RS, Taussig LM, Bacharier LB, Guilbert TW, Radford S, Sorkness CA; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma. J Allergy Clin Immunol. 2009 Apr;123(4):861-7.e1. Epub 2008 Dec 12. PubMed PMID: 19070356.

Covar RA, Szefler SJ, Zeiger RS, Sorkness CA, Moss M, Mauger DT, Boehmer SJ, Strunk RC, Martinez FD, Taussig LM. Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children. J Allergy Clin Immunol. 2008 Oct;122(4):741-747.e4. PubMed PMID: 19014765; PubMed Central PMCID: PMC3024439.

Bacharier LB, Phillips BR, Zeiger RS, Szefler SJ, Martinez FD, Lemanske RF Jr, Sorkness CA, Bloomberg GR, Morgan WJ, Paul IM, Guilbert T, Krawiec M, Covar R, Larsen G, Mellon M, Moss MH, Chinchilli VM, Taussig LM, Strunk RC; CARE Network. Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol. 2008 Dec;122(6):1127-1135.e8. Epub 2008 Oct 30. PubMed PMID: 18973936; PubMed Central PMCID: PMC2753208.

Strunk RC, Bacharier LB, Phillips BR, Szefler SJ, Zeiger RS, Chinchilli VM, Martinez FD, Lemanske RF Jr, Taussig LM, Mauger DT, Morgan WJ, Sorkness CA, Paul IM, Guilbert T, Krawiec M, Covar R, Larsen G; CARE Network. Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study. J Allergy Clin Immunol. 2008 Dec;122(6):1138-1144.e4. Epub 2008 Oct 25. PubMed PMID: 18951618; PubMed Central PMCID: PMC2737448.

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