Genetics of Dyslexia and Other Learning Disabilities
Main findings are that dyslexia is familial, moderately heritable, and linked to several quantitative trait loci. Sex chromosome anomalies also cause learning disabilities.
Pennington, B.F., & Smith, S.D. (1983).
Genetic influences
on learning disabilities and speech and language disorders.
Child Development, 54, 369-387.
Review of what was then known about genetic influences on LDs and speech and language disorders.
Pennington, B.F., Gilger, J., Pauls, D., Smith, S.A., Smith,
S.D., & DeFries, J.C. (1991).
Evidence for major gene
transmission of developmental dyslexia. Journal of the
American Medical Association, 266(11), 1527-1534.
Segregation analysis of dyslexia in four samples, which found a major gene effect.
Cardon, L.R., DeFries, J.C., Fulker, D.W., Kimberling, W.J.,
Pennington, B.F., & Smith, S.D. (1994). Quantitative
trait locus for reading disability on chromosome 6. Science,
265, 276-279.
Linkage analysis which found 6p locus for dyslexia in two samples.
Pennington, B.F., & Olson, R. (2005). Genetics of dyslesia.
In M. Snowling & C. Hulme (Eds.), The science of reading: A
handbook, pp. 453-472. Oxford: Blackwell Publishing.
Smith, S.D., Pennington, B.F., Boada, R., & Shriberg, L.D.,
(2005). Linkage of speech sound disorder to reading disability
loci. Jounral of Child Psychology and Psychiatry, 45(10), 1057-1066.
McGrath, M., Pennington, B.F., Willcutt, E.G., Shriberg, L.D., & Smith, S.D. (2007).
Gene x environment interactions in speech sound disorder predict language and preliteracy outcomes.
Development & Psychopathology Special Issue, 19, 1047-1072. PMCID: 17931434.
Pennington, B.F., McGrath, L.M., Rosenberg, J., Barnard, H., Smith, S.D., Willcutt, E.G.,
Friend, A., DeFries, J.C., & Olson, R.K. (2009). Gene x environment interactions in
reading disability and attention-deficit/hyperactivity disorder. Developmental Psychology, 45(1), 77-89.
return to top
Other Publication Areas:
Fundamental Issues
Phenotype Analyses of Dyslexia
Neuropsychological Deficts in Autism
Neuropsychology of Mental Retardation Syndromes
Genetics and Neuropsychology of
ADHD
Executive Functions
|
