Christopher M. Filley, M.D.
Dr. Filley sub-specializes in behavioral neurology. He sees patients
at the University of Colorado Hospital Anschutz Centers for Advanced Medicine
at the Fitzsimons campus, the Veterans Affairs Medical Center, and the
Colorado Mental Health Institute at Pueblo.
Dr. Filley has been involved in research on brain-behavior relationships
since joining the Department of Neurology faculty in 1984. One component
of his research has been the study of new medications for Alzheimer's
Disease (AD), and he has been an investigator in ten clinical trials to
date. One of these trials, reporting the lack of efficacy of Hydergine,
contributed significantly to the virtual abandonment of the use of this
drug in patients with AD. Dr. Filley has also participated in a wide range
of collaborative studies on other neurobehavioral disorders, including
traumatic brain injury, neurotoxic syndromes, multiple sclerosis (MS),
brain tumors, and developmental dyslexia. He has concentrated in particular
on the theoretical aspects of behavioral neurology, based on careful observations
of patients with brain disease or trauma. This work led to the publication
of his first book, Neurobehavioral Anatomy, now in its second edition.
A unifying theme of Dr. Filley's research in behavioral neurology has
been a focus on the cerebral white matter disorders. Toluene leukoencephalopathy
and multiple sclerosis have provided the foundation for much of this work,
and Dr. Filley has played a major role in many collaborative research
projects on neurologic, psychiatric, neuropsychological, neuroimaging,
and neuropathological aspects of these and other white matter disorders.
He has also formally proposed the idea of "white matter dementia"
to call attention to the cognitive deficits that can be ascribed to cerebral
white matter involvement. He is currently studying the specific patterns
of cognitive dysfunction in MS, and he is pursuing detailed studies of
toluene leukoencephalopathy using comprehensive neuropsychological testing
and advanced neuroimaging techniques. The importance of white matter in
human behavior is the topic of Dr. Filley's second book, The Behavioral
Neurology of White Matter.
Christopher M. Filley
Johns Hopkins University