Department of Mechanical and Materials Engineering
Office: Knudson Hall 204
Phone: (303) 871-4843
Ph. D. - University of California at Irvine, USA, 1997 M.S. - University of California at Irvine, USA, 1993 B.S. - University of California at Irvine, USA, 1992
Dr. Lengsfeld specialized in the fundamental behavior of sprays/droplets under extreme conditions and built one of the first micro flow laser induced fluorescence measurement systems during her time at the University of California at Irvine. Her postgraduate work was conducted at the University of Colorado at Boulder where she focused her previous spray combustion work on solving problems associated with a spray based single step manufacturing methods for the production of controlled release drug delivery particles.
Areas of Research
Currently she heads the Biofluids Laboratory at the University of Denver and has been involved in micro and nano scale pharmaceutical processing since 1997. Her group is well known for their work in using microfluidic nozzles (channel size ~200 um) to generate controllable nano size polymer particles (70 nm) for drug delivery. They just finished a long term project evaluating the aerosolization and bioprocessing of DNA and siRNA degradation and mitigation. Dr. Lengsfeld currently has significant funding to use electro-fluidic flows to generate submicron liposomes (300 to 900 nm) for drug delivery and blood substitutes. Dr. Lengsfeld has also been working to harness DNA self-propulsion by utilizing the differences in potential energy generated by molecular confinement arising from molecular length and bond limited degrees of freedom (i.e., open circular and supercoiled DNA conformations) to develop an integrated device to detect and separate similarly sized DNA molecules. These efforts have expanded into applying micro fluidic systems to rapid analysis of the mutation behavior of infectious diseases from environmental pressures; development of insole gait sensor systems to monitoring drug interactions, fall prevention in the elderly and rehabilitation of amputees; and RGO redesign. Other non-medical active programs are the flow optimization of COIL nozzles using the interface of Fluent and Nessus.