The Biofluids Lab, directed by Corinne Lengsfeld, has performed a wide variety of projects applying fluid dynamics principles to address real world problems. Applications include: developing novel encapsulation techniques to improve drug delivery, characterizing damage mechanisms of therapeutic DNA and siRNA, and improving pulmonary drug delivery by quantifying particle deposition for patients on mechanical ventilators. The lab regularly combines theory, computational fluid dynamics (CFD) modeling and experimentation at multiple scales to develop novel solutions.
Recently, fluid-solid interactions have been investigated in collaborative work with the Computational Biomechanics Lab. Fluid-solid modeling crosses the disciplinary lines of traditional CFD and particle transport with those of structural mechanics to investigate current issues in biomechanics. Three projects are currently underway:
- Simulating the dynamic behavior of the human lung
- Modeling hydrostatic stiffening effects in bone
- Fluid-enhanced wear of a total knee replacement (TKR) attachment mechanism.
These projects demonstrate capabilities that span biological scales (e.g., the lung model runs from micrometer dimension alveolar sacs to centimeter dimensions for the trachea), strongly couple the tissue/cellular response and fluid mechanics (e.g., hydrostatic stiffening does not occur in dry bone), and in combination with probabilistic methods, drive understanding of the physical behavior (e.g., wear particle transport will be dependent on particle size and shedding location).