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Knoebel Institute for Healthy Aging

Publications

Knoebel Institute for Healthy Aging

Publications

FULL TIME KIHA FACULTY PUBLICATIONS SINCE 2016

  1. Ledreux A, Boger HA, Hinson VK, Cantwell K, Granholm A-C. BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson׳s disease. Brain Res. 2016 15;1631:34-45. doi: 10.1016/j.brainres.2015.11.028. Epub 2015 Nov 19. PMID: 26607251.
  2. Maynard KR, Hill JL, Calcaterra NE, Palko ME, Kardian A, Paredes D, Sukumar M, Adler BD, Jimenez DV, Schloesser RJ, Tessarollo L, Lu B, Martinowich K (2016). Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling, Neuropsychopharmacology, 41(8):1943-55.
  3. Zhu M, Wang X, Hjorth E, Colas RA, Schroeder L, Granholm A-C, Serhan CN, Schultzberg M. Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis. Mol Neurobiol. 2016 53(4):2733-49. doi: 10.1007/s12035-015-9544-0. Epub 2015 Dec 9. PMID: 26650044.
  4. Rosenberger DS, Falangola MF, Ledreux A, Nie X, Suhre WM, Boger HA, Granholm AC. Memory and hippocampal architecture following short-term midazolam in western diet-treated rats. Neurosci Lett. 2016 May 16;621:68-74. doi: 10.1016/j.neulet.2016.04.021. Epub 2016 Apr 11. PMID: 27080429.
  5. Ledreux A, Wang X, Schultzberg M, Granholm AC, Freeman LR. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behav Brain Res. 2016 Oct 1;312:294-304. doi: 10.1016/j.bbr.2016.06.012. Epub 2016 Jun 22. PMID: 27343935.
  6. Hamlett ED, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm A-C. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Curr Alzheimer Res. 2016;13(1):35-52. PMID: 26391050.
  7. Håkansson K, Ledreux A, Daffner K, Terjestam Y, Bergman P, Carlsson R, Kivipelto M, Winblad B, Granholm A-C, Mohammed A. 2017. BDNF Responses in Healthy Older Persons to 35 minutes of Physical Exercise, Cognitive Training and Mindfulness: Associations with Working Memory Function. J Alzheimers Dis. 2017;55(2):645-657. PMID: 27716670.
  8. Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clarke D, Carroll ST, Iragui MC, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, and Granholm A-C. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome. Alzheimers Dement. 2017 13(5):541-549. doi: 10.1016/j.jalz.2016.08.012. Epub 2016 Oct 15. PMID: 27755974.
  9. Buhusi M, Etheredge C, Granholm AC, Buhusi CV. Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice. Front Aging Neurosci. 2017 Aug 31;9:284. doi: 10.3389/fnagi.2017.00284. eCollection 2017. PMID: 28912711.
  10. Bharani KL, Derex R, Granholm AC, Ledreux A. A noradrenergic lesion aggravates the effects of systemic inflammation on the hippocampus of aged rats. PLoS One. 2017 Dec 19;12(12):e0189821. doi: 10.1371/journal.pone.0189821. eCollection 2017. PMID: 29261743.
  11. Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC. Exosomal biomarkers in Down syndrome and Alzheimer's disease. Free Radic Biol Med. 2018 114:110-121. doi: 10.1016/j.freeradbiomed.2017.08.028. Epub 2017 Sep 5. Review. PMID: 28882786.
  12. Goetzl EJ, Elahi FM, Mustapic M, Kapogiannis D, Pryhoda M, Gilmore A, Gorgens KA, Davidson B, Granholm A-C, and Ledreux A. (2018) Altered levels of plasma neuron-derived exosomes and their cargo proteins characterize acute and chronic mild traumatic brain injury. FASEB J. 2019 Jan 3:fj201802319R. doi: 10.1096/fj.201802319R. [Epub ahead of print] PMID: 30605353.
  13. Betancourt L, Rada P, Hernandez L, Araujo H, Ceballos GA, Hernandez LE, Tucci P, Mari Z, De Pasquale M, Paredes DA. Micellar electrokinetic chromatography with laser induced fluorescence detection shows increase of putrescine in erythrocytes of Parkinson's disease patients. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Apr 1;1081-1082:51-57. doi: 10.1016/j.jchromb.2018.02.015. Epub 2018 Feb 13. PMID:29502029.
  14. Ahmed AA, Smoczer C, Pace B, Patterson D, Cabelof DC. Loss of DNA Polymerase beta Induces Cellular Senescence, Environmental and Molecular Mutagenesis 59:603-612, 2018, DOI 10.1002/em.22206.
  15. Thompson JA, Oukal S, Bergman H, Ojemann S, Hebb AO, Hanrahan S, Israel Z, Abosch A. Semi-automated application for estimating subthalamic nucleus boundaries and optimal target selection for deep brain stimulation implantation surgery. J Neurosurg. 2018 May 18:1-10. doi: 10.3171/2017.12.JNS171964. [Epub ahead of print] PMID: 29775152
  16. Duval N, Vacano GN, Patterson D. Rapamycin Treatment Ameliorates Age-Related Accumulation of Toxic Metabolic Intermediates in Brains of the Ts65Dn Mouse Model of Down Syndrome and Aging. Front Aging Neurosci. 2018 Sep 6;10:263. doi: 10.3389/fnagi.2018.00263. eCollection 2018. PMID: 30237765.
  17. Vacano GN, Gibson DS, Turjoman AA, Gawryluk JW, Geiger JD, Duncan M, Patterson D. Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model. Neurobiol Aging. 2018 Mar;63:96-109. doi: 10.1016/j.neurobiolaging.2017.11.010. Epub 2017 Nov 26. PMID: 29245059.
  18. Yan L, Shamir A, Skirzewski M, Leiva-Salcedo E, Kwon OB, Karavanova I, Paredes D, Malkesman O, Bailey KR, Vullhorst D, Crawley JN, Buonanno A. Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders. Mol Psychiatry. 2018 May;23(5):1233-1243. PMID: 28322273.
  19. Golshan HM, Hebb AO, Nedrud J, Mahoor MH. Studying the Effects of Deep Brain Stimulation and Medication on the Dynamics of STN-LFP Signals for Human Behavior Analysis. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:4720-4723. doi: 10.1109/EMBC.2018.8513228. PMID: 30441403.
  20. Chess E. and Greenfield J. 2019. Bridging the Gap Between Cognitive Health and Financial Capacity in Older Adults: A Scoping Review - 2019 GSA Annual Scientific Meeting.
  21. Chess E. and Greenfield J. 2019. The Importance of Early Recognition of Cognitive Decline and Financial Literacy Education for Older Adults - American Journal of Gerontology and Geriatrics.
  22. Goetzl EJ, Ledreux A, Granholm A-C, Elahi FM, Goetzl L, Hiramoto J, Kapogiannis D. Neuron-derived exosome proteins elucidate mechanisms of progression from repetitive mild traumatic brain injuries to chronic traumatic encephalopathy. Front Neurosci. 2019 May 8;13:452. doi: 10.3389/fnins.2019.00452. eCollection 2019; PMID: 31133789.
  23. Hamlett ED, LaRosa A, Mufson EJ, Fortea J, Ledreux A, Granholm AC. Exosome Release And Cargo In Down Syndrome. Dev Neurobiol. 2019 Jul 25. doi: 10.1002/dneu.22712. [Epub ahead of print] Review. PMID: 31347291.
  24. Paredes, DA, Catlow, B.J. and Sanchez-Ramos, J (2019). The Endocannabinoid System in the Aging Brain and Neurodegenerative Diseases. Integrative Neurology, Oxford University Press.
  25. Ming Ren, Zhonghua Hu, Qiang Chen, Andrew Jaffe, Yingbo Li, Vijay Sadashivaiah, Shujuan Zhu, Nina Rajpurohit, Joo Heon Shin, Wei Xia, Yankai Jia, Jingxian Wu, Sunny Lang Qin, Xinjian Li, Jian Zhu, Qingjun Tian, Daniel Paredes, Fengyu Zhang, Kuan Hong Wang, Venkata S. Mattay, Joseph H. Callicott, Karen F. Berman, Daniel R Weinberger, Feng Yang (2019) KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits. UNDER REVIEW. Molecular Psychiatric.
  26. Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, and Granholm AC (2019). Inhibitory designer receptors aggravate memory loss in a mouse model of Down syndrome. J. Neurosci.
  27. Hamlett ED, Hjorth E, Ledreux A, Gilmore A, Granholm AC*, and Schultzberg M (2019) RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome. Glia.
  28. Ledreux A, Krister Håkansson, Roger Carlsson, Laura Columbo, Yvonne Terjestam, Eliza Ryan, Erich Tusch, Kirk Daffner, Ann-Charlotte Granholm, Abdul Kadir H Mohammed (2019) Differential effects of long-term training modalities on serum BDNF levels in two healthy older adult cohorts. Journal of Alzheimer's disease.

JOINT KIHA/NSM FACULTY PUBLICATIONS

  1. Taram F, Winter AN, Linseman DA. Neuroprotection comparison of chlorogenic acid and its metabolites against mechanistically distinct cell death-inducing agents in cultured cerebellar granule neurons. Brain Res. 2016 Oct 1;1648(Pt A):69-80. doi: 10.1016/j.brainres.2016.07.028. Epub 2016 Jul 18. PMID: 27444557.
  2. Winter AN, Ross EK, Khatter S, Miller K, Linseman DA. Chemical basis for the disparate neuroprotective effects of the anthocyanins, callistephin and kuromanin, against nitrosative stress. Free Radic Biol Med. 2017 Feb;103:23-34. doi: 10.1016/j.freeradbiomed.2016.12.012. Epub 2016 Dec 13. PMID: 27986528.
  3. Winter AN, Brenner MC, Punessen N, Snodgrass M, Byars C, Arora Y, Linseman DA. Comparison of the Neuroprotective and Anti-Inflammatory Effects of the Anthocyanin Metabolites, Protocatechuic Acid and 4-Hydroxybenzoic Acid. Oxid Med Cell Longev. 2017; 2017:6297080. doi: 10.1155/2017/6297080. Epub 2017 Jun 27. PMID:28740571.
  4. Winter AN, Ross EK, Daliparthi V, Sumner WA, Kirchhof DM, Manning E, Wilkins HM, Linseman DA. A Cystine-Rich Whey Supplement (Immunocal®) Provides Neuroprotection from Diverse Oxidative Stress-Inducing Agents In Vitro by Preserving Cellular Glutathione. Oxid Med Cell Longev. 2017;2017:3103272. doi: 10.1155/2017/3103272. Epub 2017 Aug 15. PMID: 28894506.
  5. Marquardt KL, Wilkins HM, Manning E, Ignowski E, Mazzarino R, Patterson D, Swerdlow RH, and Linseman DA (2017) Induction of Bax-dependent neuronal apoptosis by amyloid-β protein precursor requires its localization to functional mitochondria. J. Syst. Integr. Neurosci. 3, doi:10.15761/JSIN.1000157.
  6. Sutcliffe TC, Winter AN, Punessen NC, Linseman DA. Procyanidin B2 Protects Neurons from Oxidative, Nitrosative, and Excitotoxic Stress. Antioxidants (Basel). 2017 Oct 13;6(4). pii: E77. doi: 10.3390/antiox6040077. PMID: 29027929.
  7. Winter AN, Ross EK, Wilkins HM, Stankiewicz TR, Wallace T, Miller K, Linseman DA. 1. An antho- cyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Nutr Neurosci. 2018 Jul;21(6):414-426. doi: 10.1080/1028415X.2017.1297023. Epub 2017 Mar 9. PMID: 28276271.
  8. Taram F, Ignowski E, Duval N, Linseman DA. Neuroprotection Comparison of Rosmarinic Acid and Carnosic Acid in Primary Cultures of Cerebellar Granule Neurons. Molecules. 2018 Nov 13;23(11). pii: E2956. doi: 10.3390/molecules23112956. PMID: 30428519.
  9. Ignowski E, Winter AN, Duval N, Fleming H, Wallace T, Manning E, Koza L, Huber K, Serkova NJ, Linseman DA. The cysteine-rich whey protein supplement, Immunocal®, preserves brain glutathione and improves cognitive, motor, and histopathological indices of traumatic brain injury in a mouse model of controlled cortical impact. Free Radic Biol Med. 2018 Aug 20;124:328-341. doi: 10.1016/j.freeradbiomed.2018.06.026. Epub 2018 Jun 27. PMID: 29940352.
  10. Duval N, Sumner WA, Andrianakos AG, Gray JJ, Bouchard RJ, Wilkins HM, Linseman DA. The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord. Front Cell Neurosci. 2018 Jan 30;12:15. doi: 10.3389/fncel.2018.00015. eCollection 2018. PMID: 29440992.
  11. Horowitz S, Salmon L, Koldewey P, Ahlstrom LS, Martin R, Quan S, Afonine PV, van den Bedem H, Wang L, Xu Q, Trievel RC, Brooks CL 3rd, Bardwell JCA. Reply to 'Misreading chaperone-substrate complexes from random noise'. Nat Struct Mol Biol. 2018 Nov;25(11):990-991. doi: 10.1038/s41594-018-0145-2. No abstract available. PMID: 30297780.
  12. Salmon L, Ahlstrom LS, Afonine P, Bardwell JCA, Horowitz S. Selecting conformational ensembles using residual electron and anomalous density (READ). Methods Mol Biol. 1764:491-504. doi: 10.1007/978-1-4939-7759-8_31 (2018) PMID: 29605935.
  13. Salmon L, Stull F, Sayle S, Cato C, Akgül Ş, Foit L, Ahlstrom LS, Eisenmesser EZ, Al-Hashimi HM, Bardwell JCA, Horowitz S. The Mechanism of HdeA Unfolding and Chaperone Activation. J Mol Biol. 2018 Jan 5;430(1):33-40. doi: 10.1016/j.jmb.2017.11.002. Epub 2017 Nov 11. PMID: 29138002.
  14. Horowitz S, Koldewey P, Stull F, Bardwell JC. Folding while bound to chaperones. Curr Opin Struct Biol. 2018 Feb;48:1-5. doi: 10.1016/j.sbi.2017.06.009. Epub 2017 Jul 19. Review. PMID: 28734135.
  15. Fick RJ, Horowitz S, McDole BG, Clay MC, Mehl RA, Al-Hashimi HM, Scheiner S, Trievel, RC. Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1. Biochemistry doi: 10.1021/acs.biochem.8b01141. (Epub 2019)
  16. Litberg TJ, Docter B, Hughes MP, Bourne J, Horowitz S (2019). DNA accelerates protein oligomerization to prevent and induce aggregation. In revision.
  17. Koza L and Linseman DA (2019) Glutathione precursors shield the brain from trauma. Neural Regen Res. 2019 Oct;14(10):1701-1702. doi: 10.4103/1673-5374.257520. No abstract available. PMID: 31169179.
  18. Dsilva L, Mittal S, Koepnick B, Flatten J, Cooper S, Horowitz S. Creating custom Foldit puzzles for teaching biochemistry. Biochem Mol Biol Educ. 2019 Mar;47(2):133-139. doi: 10.1002/bmb.21208. Epub 2019 Jan 14. PMID: 30638297.
  19. Taram F, Winter AN, Linseman DA. Neuroprotection comparison of chlorogenic acid and its metabolites against mechanistically distinct cell death-inducing agents in cultured cerebellar granule neurons. Brain Res. 2016 Oct 1;1648(Pt A):69-80. doi: 10.1016/j.brainres.2016.07.028. Epub 2016 Jul 18. PMID: 27444557.
  20. Winter AN, Ross EK, Khatter S, Miller K, Linseman DA. Chemical basis for the disparate neuroprotective effects of the anthocyanins, callistephin and kuromanin, against nitrosative stress. Free Radic Biol Med. 2017 Feb;103:23-34. doi: 10.1016/j.freeradbiomed.2016.12.012. Epub 2016 Dec 13. PMID: 27986528.
  21. Winter AN, Brenner MC, Punessen N, Snodgrass M, Byars C, Arora Y, Linseman DA. Comparison of the Neuroprotective and Anti-Inflammatory Effects of the Anthocyanin Metabolites, Protocatechuic Acid and 4-Hydroxybenzoic Acid. Oxid Med Cell Longev. 2017; 2017:6297080. doi: 10.1155/2017/6297080. Epub 2017 Jun 27. PMID:28740571.
  22. Marquardt KL, Wilkins HM, Manning E, Ignowski E, Mazzarino R, Patterson D, Swerdlow RH, and Linseman DA (2017) Induction of Bax-dependent neuronal apoptosis by amyloid-β protein precursor requires its localization to functional mitochondria. J. Syst. Integr. Neurosci. 3, doi:10.15761/JSIN.1000157.
  23. Taram F, Ignowski E, Duval N, Linseman DA. Neuroprotection Comparison of Rosmarinic Acid and Carnosic Acid in Primary Cultures of Cerebellar Granule Neurons. Molecules. 2018 Nov 13;23(11). pii: E2956. doi: 10.3390/molecules23112956. PMID: 30428519.
  24. Ignowski E, Winter AN, Duval N, Fleming H, Wallace T, Manning E, Koza L, Huber K, Serkova NJ, Linseman DA. The cysteine-rich whey protein supplement, Immunocal®, preserves brain glutathione and improves cognitive, motor, and histopathological indices of traumatic brain injury in a mouse model of controlled cortical impact. Free Radic Biol Med. 2018 Aug 20;124:328-341. doi: 10.1016/j.freeradbiomed.2018.06.026. Epub 2018 Jun 27. PMID: 29940352.
  25. Dsilva L, Mittal S, Koepnick B, Flatten J, Cooper S, Horowitz S. Creating custom Foldit puzzles for teaching biochemistry. Biochem Mol Biol Educ. 2019 Mar;47(2):133-139. doi: 10.1002/bmb.21208. Epub 2019 Jan 14. PMID: 30638297.
  26. Horowitz S, Salmon L, Koldewey P, Ahlstrom LS, Martin R, Quan S, Afonine PV, van den Bedem H, Wang L, Xu Q, Trievel RC, Brooks CL 3rd, Bardwell JCA. Reply to 'Misreading chaperone-substrate complexes from random noise'. Nat Struct Mol Biol. 2018 Nov;25(11):990-991. doi: 10.1038/s41594-018-0145-2. No abstract available. PMID: 30297780.
  27. Salmon L, Ahlstrom LS, Afonine P, Bardwell JCA, Horowitz S. Selecting conformational ensembles using residual electron and anomalous density (READ). Methods Mol Biol. 1764:491-504. doi: 10.1007/978-1-4939-7759-8_31 (2018) PMID: 29605935.
  28. Salmon L, Stull F, Sayle S, Cato C, Akgül Ş, Foit L, Ahlstrom LS, Eisenmesser EZ, Al-Hashimi HM, Bardwell JCA, Horowitz S. The Mechanism of HdeA Unfolding and Chaperone Activation. J Mol Biol. 2018 Jan 5;430(1):33-40. doi: 10.1016/j.jmb.2017.11.002. Epub 2017 Nov 11. PMID: 29138002.
  29. Horowitz S, Koldewey P, Stull F, Bardwell JC. Folding while bound to chaperones. Curr Opin Struct Biol. 2018 Feb;48:1-5. doi: 10.1016/j.sbi.2017.06.009. Epub 2017 Jul 19. Review. PMID: 28734135.
  30. Fick RJ, Horowitz S, McDole BG, Clay MC, Mehl RA, Al-Hashimi HM, Scheiner S, Trievel, RC. Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1. Biochemistry doi: 10.1021/acs.biochem.8b01141. (Epub 2019)
  31. Litberg TJ, Docter B, Hughes MP, Bourne J, Horowitz S (2019). DNA accelerates protein oligomerization to prevent and induce aggregation. In revision.
  32. Koza L and Linseman DA (2019) Glutathione precursors shield the brain from trauma. Neural Regen Res. 2019 Oct;14(10):1701-1702. doi: 10.4103/1673-5374.257520. No abstract available. PMID: 31169179.