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Division of Natural Sciences & MathematicsDepartment of Biological Sciences

Faculty & Staff

Assistant Professor

Schuyler van Engelenburg

Schuyler van Engelenburg  

Office: SG Mudd 353

Office Phone: (303) 871-3534

E-mail: schuyler.vanengelenburg@du.edu 

Degrees

  • 2005 B.S., Chemistry – Fort Lewis College – Durango, CO
  • 2010 Ph.D., Biochemistry – University of Colorado – Boulder, CO
  • 2010-2014 NIH Postdoctoral Fellow, Cell Biology and Metabolism Program, NICHD – Bethesda, MD

Research Interests

Host-cell factors involved in promoting virus assembly and release:

Our laboratory is focused on understanding the mechanisms by which viral components usurp host cell machinery to carry out virus assembly and propagation. Specifically, we are interested in the ways in which enveloped viruses, such as Human Immunodeficiency Virus (HIV), hijack membrane remodeling components to mediate virus assembly and release. This research is enabled by the use of advanced fluorescence microscopy technologies such as three-dimensional point-localization superresolution imaging (PALM/STORM), which provides unparalleled cellular resolution and molecular specificity at < 50 nanometer spatial scales. Additionally, we use single-molecule FRET to probe the dynamics of key biomolecules at spatial scales < 10 nanometers. Combined these techniques allow us to spy on virus and host cell molecules in order to understand the structural principles that govern cellular and molecular function. Projects in the laboratory use a variety of supplementary techniques such as: mammalian cell culture, molecular biology, biochemistry, fluorescent probe/protein engineering, and image analysis to enable quantitative measurements of molecular and cellular systems. It is expected that these measurements will enable construction of accurate models of the host-pathogen interface with the eventual goal of therapeutic exploitation of viral dependencies.

View van Engelenburg's publications through PubMed