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A Novel Photochemical Approach in the Synthesis of β-Lactams

β-Lactam antibiotics are amongst the most pivotal and ubiquitous antimicrobial compounds worldwide. These compounds, characterized by a defining chemical feature - the β-lactam ring – a four-membered ring containing an amidic function, represent adiverse and broad family of molecules. The persistent use of these compounds has fueled the emergence of resistant microorganisms, prompting intensive eForts to discover and synthesize new β-Lactam varieties with the goal of improving biological activity. Total laboratory synthesis of β-lactam antibiotics remains a formidable challenge due to the complex chirality and function of these molecules.

This research introduces a novel photochemical approach for the synthesis of β-lactam-containing molecules. Through extensive experimentation and optimization, this study increased yields from 27% to 71% in one model reaction, providing a successful and eFicient means of synthesis with considerable scale-up opportunity using a flow reactor. After experimentation with various photo-precursors, eFective isolation, and characterization of two β-Lactam-containing products serve as evidence to support the synthetic viability of this reaction, providing a new and eFicient means of β-Lactam synthesis.